摘要
目的:观察康莱特软胶囊联合氩氦刀冷冻消融术治疗晚期非小细胞肺癌的临床疗效。方法:选取40例非小细胞肺癌患者作为研究对象,随机分为对照组和试验组,均于常规化疗后行氩氦刀冷冻消融术治疗,试验组加用康莱特软胶囊口服。观察两组患者临床疗效、生存质量改善情况及不良反应发生情况,随访记录两组患者总生存时间及病灶进展时间。结果:试验组临床有效率为55.0%,对照组临床有效率为40.0%,试验组优于对照组,差异有统计学意义(P<0.05);治疗后两组患者生存质量均较治疗前有所改善,且试验组改善情况优于对照组,两组比较,差异有统计学意义(P<0.05);试验组患者总生存时间及病灶进展时间较对照组明显延长,不良反应较轻,两组比较,差异有统计学意义(P<0.05)。结论:晚期非小细胞肺癌化疗后,采用康莱特软胶囊联合氩氦刀冷冻消融术治疗,可提高患者生存质量,延长生存期,减轻不良反应,延长肿瘤进展时间。
Objective：To observe the clinical effect of Kanglaite soft capsule combined with argon-helium cryopreservation in the treatment of advanced non-small cell lung cancer（NSCLC）.Methods：Forty patients with NSCLC were randomly divided into two groups.All the patients received the treatment of argon-helium cryopreservation after standard chemotherapy,and experimental group addition Kanglaite soft capsule.The efficacy,time to progression,overall survival time and adverse reactions were observed in each group.Results：The clinical effective rate was 55.0% in the experimental group and 40.0% in the control group.The experimental group was superior to the control group（P0.05）.After treatment,the quality of life was improved in both groups,and the improvement in the experimental group was better than that in the control group.The difference between the two groups was statistically significant（P0.05）.The total survival time and lesion progression time in the experimental group were significantly longer than those in the control group,and the adverse reactions were lighter.The difference between the two groups was statistically significant（P0.05）.Conclusion：After chemotherapy,the use of Kanglaite soft capsule combined with argon-helium cryopreservation in the treatment of NSCLC can improve the quality of survival,prolong the survival period,reduce adverse reactions,decrease the rate of recurrence and metastasis and extend the time of tumor progression.
作者
李靖
黎海亮
郭晨阳
肖金成
郑琳
赵妍
LI Jing, LI Hailiang, GUO Chenyang, XIAO Jincheng,ZHENG Lin, ZHAO Yan(Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou Henan China 45000)
出处
《中医学报》
CAS
2018年第2期190-193,共4页
Acta Chinese Medicine
基金
河南省医学科技攻关计划项目(201702261)
关键词
非小细胞肺癌
肿瘤
康莱特软胶囊
氩氦刀冷冻消融术
生存质量
总生存时间
病灶进展时间
中医药治疗
中西医结合
advanced non-small cell lung cancer
tumor
Kanglaite soft capsule
argon-helium cryopreservation
quality of life
overall survival time
time of disease progression
TCM therapy
combination of traditional Chinese and Western medicine
