摘要
激光光热治疗被认为是有潜在应用价值的肿瘤微创/无创治疗技术,具有快速、微创、毒副作用小等优点,因而受到了广泛关注。为提高光热治疗效果,研究人员对不同类型的光热治疗剂进行了研究。相比于无机纳米材料,基于有机材料的光热治疗剂具有更理想的生物相容性和生物降解性能,更容易实现临床应用,因此近年来发展迅速。对典型的有机光热治疗剂(包括包裹近红外染料的纳米胶束、基于蛋白结构的光热治疗剂、卟啉脂质体和聚合物近红外吸收材料)在近年来的研究进展进行阐述,介绍了它们各自的优势和存在的问题,最后对本领域的研究方向进行思考和探讨。
Laser-induced thermal therapy,which has many advantages including rapid operation,minimal damage and insignificant toxicity and side effects,is considered to be a promising non-invasive/minimally invasive therapeutic methodology,and it attracts much attention in recent years.In order to improve the therapeutic effects,researchers study various types of photothermal therapy agents（PTAs）.Compared with inorganic nanomaterials,PTAs based on organic nanomaterials have superior biocompatibility and biodegradability,and they are more promising for clinical translation.As a result,PTAs based on organic nanomaterials has rapid development in recent years.In this review,the recent progress of several typical classes of organic photothermal nano-agents,including near-infrared dye-containing micelles,protein-based photothermal agents,porphysomes,and conjugated polymers,is introduced,and their individual advantages and shortcomings are introduced.At last,the challenges and future direction of this field also be discussed.
作者
梁国海
邢达
Liang Guohai, Xing Da(Key Laboratory of Laser Life Science, Ministry of Education, College of Biophotonics, South China Normal University Guangzhou, Guangdong 510631, Chin)
出处
《中国激光》
EI
CAS
CSCD
北大核心
2018年第2期241-250,共10页
Chinese Journal of Lasers
基金
国家自然科学基金(81630046)
华南师范大学青年教师培育基金(671074)
关键词
医用光学
光热治疗
近红外
光热转换
有机纳米材料
medical optics
photothermal therapy
near-infrared
photothermal conversion
organic nanomaterial
