摘要
目的：探讨不同眼压水平对青少年近视进展的影响。方法：前瞻性队列研究。选取2014 年7 月至2015 年12 月就诊于长沙爱尔眼科医院的6～18 岁儿童青少年近视患者112 例（112 眼）。根据基线平均眼压（IOP）值分成3组：高眼压组（21 mmHg 〈 平均IOP 〈 30 mmHg）、中等眼压组（15 mmHg〈平均IOP≤21 mmHg）和低眼压组（10 mmHg 〈 平均IOP≤15mmHg）。每6个月随访1次，共3次；记录24 h IOP、等效球镜度（SE）、眼轴长度（AL）和中央角膜厚度（CCT）。组间IOP、SE、AL比较采用单素方差分析，随访中IOP、SE、AL及各指标进展值采用重复测量的方差分析，并采用Logistic回归分析可能导致近视进展的影响因素。结果：最终103 例完成随访研究。青少年SE进展程度为：高眼压组（-0.87±0.90）D/年，中等眼压组（-0.59±0.89）D/年，低眼压组（-0.33±0.32）D/年（F=5.848，P=0.017）。AL的增长情况为：高眼压组（0.40±0.29）mm/年，中等眼压组（0.18±0.31）mm/年和低眼压组（0.17±0.30）mm/年（F=5.265，P=0.007）。平均IOP较高的青少年更可能发生SE的进展（OR=0.454，95%CI=0.317～0.716，P=0.007），而年龄较小的儿童青少年其AL更容易延长（OR=1.433，95%CI=0.994～1.506，P=0.015）。结论：IOP水平较高的儿童青少年近视进展较快，表现在SE的增加和AL的延长，说明IOP水平在儿童青少年近视进展中起到了重要的作用。
Objective： To investigate the effect of intraocular pressure （IOP） on myopia progression in adolescents.Methods： This was a prospective study of 112 myopia subjects （ages 6-18 years old） in Changsha Aier Hospital from July 2014 to December 2015. Depending on the mean IOP at baseline, the subjects were categorized into three groups： High IOP （IOPH, 21 mmHg 〈 mean IOP 〈 30 mmHg）, moderate IOP （IOPM,15 mmHg 〈 mean IOP ≤ 21 mmHg）, and low IOP （IOPL, 10 mmHg 〈 mean IOP ≤ 15 mmHg）. Regular follow-ups were at 6, 12, and 18 months after baseline. Twenty-four hour IOP, spherical equivalent （SE）,axial length （AL）, and central corneal thickness were measured at each follow-up visit. Repeated measures analysis of variance and logistic regression analysis were performed to estimate the factors influencing
SE and AL. Results： At last, 103 cases finish the follow-up. The rates of SE progression for each group were determined for the 18-month follow-up period. For the IOPH group, IOPM group, IOPL group, the SE progression rate was -0.87±0.90 diopter （D）/year, -0.59 ± 0.89 D/year, -0.33 ± 0.32 D/year respectively,the rate of change in SE over the study period was significant （F=5.848, P=0.017）. The rates of AL change for each group were also determined. For the IOPH group, IOPM group, IOPL group, the rate was 0.40 ± 0.29 mm/year, 0.18 ± 0.31 mm/year, 0.17 ± 0.30 mm/year respectively , the rate of change in AL over the study period was significant （F=5.265, P=0.007）. Eyes with higher mean IOPs were likely to have SE progression （OR=0.454, 95%CI=0.317-0.716, P=0.007）. Younger subjects were likely to have greater AL
elongation than older subjects （OR=1.433, 95%CI=0.994-1.506, P=0.015）. Conclusions： Adolescents with higher mean IOPs are associated with the SE changes that are consistent with the changes in AL elongation.These findings suggest that IOP plays a major role in myopia progression in adolescents.
作者
邓媛
荣敏娜
邓文
曹兴
李雯
周丹
叶长华
Yuan Deng1,2, Minna Rong1, Wen Deng1, Xing Cao1, Wen Li1, Dan Zhou1, Changhua Ye1(1Changsha Aier Eye Hospital, Aier School of Ophthalmology, Central South University, Changsha 410015, China 2Changsha Health Vocation College, Changsha 410100, Chin)
出处
《中华眼视光学与视觉科学杂志》
CAS
CSCD
2018年第3期133-138,共6页
Chinese Journal Of Optometry Ophthalmology And Visual Science
基金
爱尔眼科集团科研基金（AF146D14）
关键词
眼压
近视
儿童
青少年
intraocular pressure
myopia
children
adolescent
