摘要
目的探讨急性sT段抬高型心肌梗死（STEMI）患者入院中性粒细胞淋巴细胞比值（NLR）与冠脉病变严重程度的关系。方法纳入首都医科大学附属北京安贞医院急诊危重症中心2016年8月至2017年4月收治的STEMI行冠状动脉造影患者，采用Gensini评分评价冠脉病变严重程度，分析不同程度冠脉病变患者的基线资料特点。通过受试者工作特征曲线（ROC）分析NLR对冠脉病变严重程度的评估价值。采用多因素Logistic回归分析探讨NLR与冠脉病变严重程度的相关性。结果共纳入行冠脉造影的STEMI患者277例．按GS评分中位数将患者分为低分（GS≤56）及高分（GS〉56）两组。GS高分组入院NLR值较高，与低分组相比差异有统计学意义（P=0．03）。ROC曲线分析提示，NLR为7．96时对GS评分的预测性最强。NLR≤7．96组与NLR〉7．96组相比，Gs评分明显升高，差异有统计学意义（P〈0．001）。多因素Logistic回归提示，NLR是严重冠脉病变的独立危险因素（OR=1．09，95％CI1.03-1．17，P=0．007）。结论STEMI患者人院NLR与Gensini评分呈正相关，是严重冠脉病变的独立危险因素。
Objective To assess the relationship between Neutrophil-lymphocyte Ratio （NLR） and the severity of coronary artery disease. Methods STEMI patients who was undergoing angiography from August, 2016 to April 2017 at Beijing Anzhen hospital were included. Gensini score was used to evaluate the severity of coronary artery disease. Receiver-operating characteristic（ROC ） curve analysis was performed to determine the cut-off point of NLR to predict high GS score. Multivariate logistic regression analyses were used to identify independent predic- tors of high GS score in the whole study population. Results A total of 277 STEMI patients who were undergoing angiography were included. According to the median value of GS, patients were divided into two groups. Patients with higher GS（GS〉56 ） had a higher NLR value. And NLR value was positive correlated with GS score. The mul- tivariate logistic analysis showed that NLR was an independent predictor of GS score. Conclusion NLR is positive related to the severity of coronary artery disease with Gensini score. And it is an independent predictor of higher GS score in STEMI patients.
作者
范婧尧
王晓
周生辉
聂绍平
FAN Jing-yao, WANG Xiao, ZHOU Sheng-hui, et al.(Emergency ＆ Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, Chin)
出处
《中国心血管病研究》
CAS
2018年第2期123-126,共4页
Chinese Journal of Cardiovascular Research
基金
国家国际科技合作专项(项目编号:2015DFA30160)
国家高技术研究发展计划(863)重大项目(项目编号:2015AA020102)
北京市自然科学重点项目(项目编号:7141003)
北京市医管局重点医学发展计划(项目编号:ZYLX201710)
