摘要
目的探讨白藜芦醇软胶囊对2型糖尿病患者血糖变异及胰岛素抵抗的影响。方法采用随机数字表法将2型糖尿病80例分为A、B、C、D 4组:每组20例,A、B、C组在基础治疗上加白藜芦醇软胶囊。其中,A组:250 mg/次,口服,2次/d;B组:350 mg/次,口服,2次/d;C组:500 mg/次,口服,2次/d,治疗12周;D组为对照组(基础治疗);检测空腹血糖(FPG)、空腹胰岛素(FISN)糖化血红蛋白(Hb A1c)、血脂、胰岛素及三餐2h后血糖,计算MBG、血糖波动参数、胰岛素抵抗指数(HOMA-IR)和胰岛素敏感指数(ISI)。结果 C组和D组治疗前后各值均数差F各值均数差FPG:[(1.54±0.06)mmol/L vs(0.45±0.01)mmol/L,t=4.562,P=0.037)];FISN:[(4.85±0.35)pmol/ml vs(0.76±0.13)pmol/ml,t=3.467,P=0.025];Hb A1c:[(1.01±0.36)%vs(0.24±0.07)%,t=3.724,P=0.031];平均血糖值:[(1.91±0.22))mmol/L vs(0.33±0.03)mmol/L,t=4.823,P=0.026];血糖变异性:[(1.22±0.23)mmol/L vs(0.07±0.03)mmol/L,t=4.025,P=0.027];血糖标准差:[(0.88±0.12)vs(0.02±0.01),t=3.681,P=0.032]较治疗前明显下降。C组治疗前后HOMA-IR由2级均降至1级、ISI的改善C组优于D组(P<0.01)。结论白藜芦醇软胶囊对血糖变异及胰岛素抵抗与剂量相关,一定剂量的白藜芦醇软胶囊可降低2型糖尿病患者的平均血糖波动度、血糖标准差,减少HOMA-IR,提高ISI;2型糖尿病患者在服用降糖药的同时,联合服用白藜芦醇软胶囊治疗是较好的选择。
Objective To explore the effect of resveratrol soft capsules on glucose variability in patients with type 2 diabetes and on insulin resistance. Methods Using the random number table method,80 patients with type 2 diabetes were equally divided into four groups. Group A,B and C were given resveratrol soft capsules for twelve weeks plus conventional treatment. Group A orally took resveratrol soft capsules 250 mg twice a day,Group B 350 mg,Group C 500 mg,while Group D served as the control group（conventional treatment）. Fasting blood glucose,blood lipids,insulin and serum glucose 2 h after meals were detected. MBG,serum glucose fluctuation parameters,the index of insulin resistance（HOMA IR） and insulin sensitive index（ISI） were calculated. Results FPG in Group C and Group D before and after treatment was[（1. 54 ± 0. 06） mmol/L vs（0. 45 ± 0. 01） mmol/L,t = 4. 562,P = 0. 037） ]respectively,FISN was[（4. 85 ± 0. 35） pmol/ml vs（0. 76 ± 0. 13） pmol/ml,t = 3. 467,P = 0. 025]respectively,and Hb A1 c was[（1. 01± 0. 36） % vs（0. 24 ± 0. 07） %,t = 3. 724,P = 0. 031]respectively. The average serum glucose value was[（1. 91 ± 0. 22） mmol/L vs（0. 33 ± 0. 03） mmol/L,t = 4. 823,P = 0. 026]respectively,serum glucose variability was[（1. 22 ± 0. 23） mmol/L vs（0. 07 ± 0. 03）mmol/L,t = 4. 025,P = 0. 027]respectively,and serum glucose standard deviation was[（0. 88 ± 0. 12） vs（0. 02 ± 0. 01）,t = 3. 681,P = 0. 032]. After treatment,HOMA IR in Group C was reduced from Grade Two to Grade One,and the ISI of Group C improved more significantly than that of Group D（P 0. 01）. Conclusions A particular dose of resveratrol soft capsules can reduce the average serum glucose,daytime serum glucose fluctuations,standard deviations of serum glucose and HOMA IR while improving ISI in patients with type 2 diabetes. Patients with type 2 diabetes should take resveratrol soft capsules in combination with other antidiabetic drugs.
作者
张娴
刘莉
ZHANG Xian and LIU Li(Department of Servicemen, Yunnan Provincial Corps Hospital of Chinese People＇ s Armed Police Force, Kunming 650111, Chin)
出处
《武警医学》
CAS
2018年第1期52-56,共5页
Medical Journal of the Chinese People's Armed Police Force
基金
云南省昆明市西山区基金课题项目(西-2014012)
关键词
白藜芦醇软胶囊
2型糖尿病
血糖变异
胰岛素抵抗
resveratrol soft capsule
type 2 diabetes
glucose variability
insulin resistance index
