摘要
目的探讨硫酸沙丁胺醇联合布地奈德雾化治疗小儿支气管哮喘急性发作的效果并研究其可能的机制,为进一步指导临床对小儿哮喘的诊疗。方法选取95例支气管哮喘急性发作期患儿作为研究对象,其中47例采用硫酸沙丁胺醇联合布地奈德雾化治疗的患儿为联合组,48例采用硫酸沙丁胺醇雾化治疗的患儿为对照组,两组其余基础治疗保持一致,对比两组治疗效果及治疗前、后的血白三烯(LTC4)、尿白三烯(LTE4)、嗜酸性粒细胞(EOS)、免疫球蛋白E(Ig E)、γ-干扰素(IFN-γ)的水平。结果治疗前两组患儿的LTC4、LTE4、EOS、Ig E、IFN-γ、FEV1%、PEF%水平差异无统计学意义(P>0.05);治疗后联合组患儿LTC4、LTE4、EOS、Ig E水平显著低于对照组患儿,IFN-γ、FEV1%、PEF%水平显著高于对照组患儿,差异均有统计学意义(P<0.05)。治疗后两组患儿的LTC4、LTE4、EOS、Ig E水平较治疗前显著的降低,IFN-γ、FEV1%、PEF%水平较治疗前显著的提高,差异均有统计学意义(P<0.05)。治疗前两组患儿的咳嗽、喘息、呼吸困难、肺部哮鸣音评分差异无统计学意义(P>0.05);治疗后两组患儿的咳嗽、喘息、呼吸困难、肺部哮鸣音评分较治疗前显著的降低,且联合组显著低于对照组,差异均有统计学意义(P<0.05)。结论布地奈德雾化治疗小儿支气管哮喘急性发作能有效降低LTC4、LTE4、EOS、Ig E水平,提高IFN-γ水平,具有较好的临床疗效。
Objective To explore the effect of salbutamol sulfate combined with budesonide in treatment of acute attack of bronchial asthma in children,research the possible mechanism,and further direct diagnosis and treatment of children with asthma. Methods A total of 95 children with bronchial asthma during acute attack period were selected and divided into combination group and control group： 47 children in combination group were treated by atomization inhalation of salbutamol sulfate combined with budesonide,and 48 children in control group were treated by atomization inhalation of salbutamol sulfate. Basic therapy was given to the children in the two groups. The curative effects,the levels of blood leukotrienes（ LTC4）,urine leukotrienes（ LTE4）,eosnophils（ EOS）,immunoglobulin E（ Ig E）,and interferon-γ（ IFN-γ） before and after treatment in the two groups were compared. Results Before treatment,there was no statistically significant difference in the levels of LTC4,LTE4,EOS,Ig E,IFN-γ,FEV1%,and PEF% between the two groups（ P0. 05）. After treatment,the levels of LTC4,LTE4,EOS,and Ig E in combination group were statistically significantly lower than those in control group（ P0. 05）,the levels of IFN-γ,FEV1%,and PEF% in combination group were statistically significantly higher than those in control group（ P0. 05）. After treatment,the levels of LTC4,LTE4,EOS,and Ig E in the two groups were statistically significantly lower than those before treatment（ P0. 05）,the levels of IFN-γ,FEV1%,and PEF% were statistically significantly higher than those before treatment（ P0. 05）. Before treatment,there was no statistically significant difference in the scores of cough,wheeze,dyspnea,and lung wheezing rales between the two groups（ P0. 05）. After treatment,the scores of cough,wheeze,dyspnea,and lung wheezing rales in the two groups were statistically significantly lower than those before treatment（ P0. 05）. The scores of cough,wheeze,dyspnea,and lung wheezing rales after treatment in
出处
《中国妇幼保健》
CAS
2018年第6期1331-1334,共4页
Maternal and Child Health Care of China
