摘要
目的调查结直肠癌手术患者围手术期抗菌药物使用情况,为临床合理使用抗菌药物提供依据。方法抽取某院2014~2016年结直肠癌手术病例300例,对其分组进行回顾性调查,对围术期抗菌药物品种选择、给药时机、持续用药时间及联合用药等情况进行统计分析。结果 2014~2016年间,抗菌药物预防性用药率为100%,使用频次前3的品种为哌拉西林舒巴坦(依次占57.0%,56.8%,70.4%)、甲硝唑(依次占34.2%,30.1%,23.5%)、头孢米诺钠(依次占5.1%,11.0%,3.8%)。联合用药以甲硝唑与β-内酰胺类联用为主(依次占98.2%,97.7%,95.8%),术中追加抗菌药物合理率稍有上升(依次占2.7%,6.9%,5.0%),近3年间,围术期48 h内预防用抗菌药物呈下降趋势(依次占76%,65%,60%),大于48 h持续用药呈上升趋势。术后感染率依次为14%,9%,9%。结论某院结直肠癌围术期抗菌药物的使用仍存在用药时机选择不当、术中追加抗菌药物合理率较低、术后持续用药时间过长、联合用药不合理等现象,应进一步加强围手期抗菌药物的管理,确保安全合理用药。
OBJECTIVE To investigate the perioperative use of antibiotics in patients with colorectal cancer surgery,and to provide a basis for the clinical use of antibiotics. METHODS A total of 300 cases of colorectal cancer surgery in 2014 ~ 2016 years in a hospital were selected analyzed retrospectively. The selection of antibiotics,timing of medication,duration of continuous medication and combined medication were analyzed statistically. RESULTS In the past 3 years,the rate of prophylactic use of antibiotics was 100%,the highest frequency was piperacillin sulbactam（57%,56.8%,70.4%）,metronidazole（34.2%,30.1%,23.5%）,cephalosporin Mino（ 5.1%,11%,3.8%）. Combination therapy mainly were metronidazole and beta lactam combination（ mainly accounted for 98.2%,97.7%,95. 8% respectively）,additional intraoperative antibiotics reasonable rate rose slightly（accounted for 2. 7%,6. 9%,5%respectively）.In the past three years,the rates of perioperative prophylactic use of antibiotics within 48 h were reduced（ 76%,65%,60%respectively）. The continuous use of drugs greater than 48 h was on the rise.The postoperative infection rate in the past three years was14%,9% and 9%,respectively. CONCLUSION Antimicrobial drug use in colorectal cancer patients with colorectal surgery has long usage during,improper time and more combination use,which need to strengthen management further.
出处
《今日药学》
CAS
2018年第2期130-133,144,共5页
Pharmacy Today
基金
广东省医院药学科研基金(2015SW15)
广东省医学科学技术研究基金(A2015439)
关键词
结直肠癌
围手术期
抗菌药物
colorectal cancer
pcrioperative period
antiseptic drugs
