摘要
埃洛石是一种广泛应用的天然纳米管状材料。研究了纯化后的埃洛石经口服后对小鼠的肝脏的毒性.实验按口服纯化埃洛石的剂量不同分为4组:对照组,4,20和100mg/kg BW组.实验结果表明,低剂量(4mg/kg BW)的埃洛石对小鼠的肝脏没有毒性,且可促进小鼠体重增长;而当剂量高于20 mg/kg BW时小鼠的肝脏产生氧化应激反应,体重增长也受到抑制.而且,高剂量的埃洛石还会导致Al在肝脏聚集,并导致肝脏功能障碍和病理变化.
Halloysite is widely used in many fields due to its natural hollow nanotubular structure.To assess the liver toxicity of the purified halloysite nanotubes（HNTs）in mice via oral route,purified HNTs were orally administered to mice at 4,20and 100mg/kg BW body weight（BW）every day for 30d.Oral administration of HNTs stimulates the growth of the mice at low dose（4mg/kg BW）with no liver toxicity,but inhibits the growth of the mice and induces oxidative stress in the liver at high dose（≥20 mg/kg BW）.In addition,oral administration of HNTs at high dose causes Al accumulation in liver,which induces hepatic dysfunction and histopathologic changes.
基金
Supported by the National Natural Science Foundation of China(21171157,20871111,20571069)
关键词
埃洛石纳米管
体内毒性
肝脏
Halloysite
natural hollow nanotubular structure
liver toxicity
purified halloysite nanotubes（HNTs）
HNTs stimulates
