摘要
目的探讨奥沙利铂联合肝动脉化疗栓塞术治疗老年原发性肝癌患者的临床疗效。方法选择我院2013年1月至2017年7月收治的103例老年原发性肝癌患者为研究对象，按随机数字表法分为观察组和对照组。其中观察组51例，给予肝动脉化疗栓塞术联合奥沙利铂治疗；对照组52例，给予传统肝动脉化疗栓塞术治疗。对比分析两组患者临床治疗效果及其不良反应发生情况。结果观察组患者部分缓解率36．0％和总有效率72．6％均高于对照组的50．0％和50．0％（χ2=4．555和5．511，P=0．033和0．019）。两组患者不良反应发生情况比较差异无统计学意义（均P〉0．05）。结论奥沙利铂联合肝动脉化疗栓塞术治疗老年原发性肝癌患者疗效较好，且不会增加患者的不良反应发生率。
Objective To explore the clinical efficacy and safety of Oxaliplatin combined with transcatheter arterial chemoembolization in the treatment of elderly patients with primary hepatocellular carcinoma. Methods One-hundred and three elderly patients with primary hepatocellular carcinoma who were treated in First Affiliated Hospital of Bengbu Medical College from January 2013 to July 2017 were selected. Based on the treatment methods, all patients were divided into the observation group and the control group by random number table method. Patients in the observation group （n=51） were treated with transcatheter arterial chemoembolization combined with Oxaliplatin, and those in the control group （n = 52 ） treated with traditional hepatic arterial chemoembolization. The clinical efficacy and adverse reactions were compared and analyzed between groups. Results In the observation group, the partial remission rate （70.6% vs 50%, χ2 = 4.555, P=0.033） and the total effective rate （72.6% vs. 50%, χ2 =5.511, P=0.019） were significantly higher than those in the control group. Additionally, there was no significant difference in the incidence of adverse reactions between the two groups （all P〉0.05）. Conclusions Combined with transcatheter arterial chernoembolization, Oxaliplatin could safely and effectively improve the prognosis of elderly patients with primary hepatocellular carcinoma..
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2018年第3期288-290,共3页
Chinese Journal of Geriatrics
基金
蚌埠医学院科技发展基金项目（BYKF1793）
安徽省教育厅一般项目（KJ2015B089）
关键词
栓塞
治疗性
肝肿瘤
Oembolization,therapeutic
Liver neoplasms
