摘要
目的:研究黑果枸杞酚性成分。方法:采用多种色谱法分离纯化其化合物,并借助谱学方法鉴定其化学结构。结果:从中分离得到14个化合物,分别命名为榕醛(1)、4,6-二羟基苯甲酸甲酯-2-O-β-D-葡萄糖苷(2)、马栗树皮素(3)、对羟基肉桂酸葡萄糖酯(4)、反式阿魏酸(5)、反式咖啡酸(6)、对甲氧基肉桂酸(7)、对羟基肉桂酸(8)、二氢阿魏酸甲酯(9)、香草酸(10)、原儿茶酸(11)、对羟基苯甲酸(12)、原儿茶醛(13)和(E)-2-丁烯二酸单甲酯(14)。结论:化合物1~4、7、9和14为首次从黑果枸杞中分离得到,对化合物1和2测试了Sirtuin 1(SIRT1)和Sirtuin 6(SIRT6)的活性。
Objective： To study phenolic compounds from the fruits of Lycium ruthenicum Murr. Methods： Compounds were isolated by using column chromatography and their structures were elucidated by spectroscopic methods. Results： Fourteen compounds isolated from L. ruthenicum were identified as ficusal（1）,methyl 2-O-β-D-glucopyranosyl-2,4,6-trihydroxybenzoate（2）,esculetin（3）,p-coumaric acid glucosyl ester（4）,trans-ferulic acid（5）,trans-caffeic acid（6）,（E）-4-methoxycinnamic acid（7）,4-hydroxycinnamate（8）,dihydroferulic acid methyl ester（9）,vanillic acid（10）,protocatechuic acid（11）,4-hydroxybenzoic acid（12）,protocatechuic aldehyde（13）,and（E）-but-2-enedioic acid monomethyl ester（14）,respectively. Conclusion： Compounds 1-4,7,9,and 14 were isolated from the title species for the first time. In addition,the activities of compounds 1 and 2 towards SIRT1 and SIRT6 were tested.
出处
《中国现代中药》
CAS
2018年第2期159-162,178,共5页
Modern Chinese Medicine
基金
国家杰出青年科学基金(81525026)
