摘要
目的对161例黑色素瘤患者的临床特征进行分析,以了解其在河南省的流行病学特点及预后相关因素。方法回顾性分析河南省2011年7月—2014年7月收治的161例黑色素瘤患者的临床和病理资料,并对其生存情况进行随访和分析。利用SPSS17.0软件进行分析,Kaplan-Meier法绘制生存曲线,生存时间的比较采用log-rank检验,采用Cox回归进行生存分析。结果 161例黑色素瘤患者男性65例(40.4%),女性96例(59.6%)。中位年龄为57岁。皮肤及粘膜是主要的发病部位。多因素生存分析显示就诊时有无淋巴结转移及是否行辅助治疗是影响生存期的独立预后因子。结论黑色素瘤发病率低,恶性程度高,2年生存率不足33.3%。所有患者的预后与初诊时淋巴结转移和辅助治疗有关。
Objective To analyze the clinical characters of 161 cases with malignant melanoma in Henan province to identify the epidemiological characteristics and prognostic factors of malignant melanoma in Henan. Methods The clinicopathological data of 161 patients with malignant melanoma in Henan province between July 2011 to July 2014 were retrospectively reviewed,and the survival was analyzed. The survival curves were calculated by Kaplan-Meier method and log-rank was used for survival analysis,analysis of survival using Cox regression. Results Of 161 patients with maligant melanoma there were 65 males and 96 female,median age 57 years. Skin and mucosal type were major type. Multivariate analysis showed that lymph node metastasis and systemic therapy have impact on the survival of patients.Conclusion Malignant melanoma is rare,and 2 year survival rate is less than 33. 3%. The prognosis was closely to the lymph node metastasis and systemic therapy.
出处
《医药论坛杂志》
2018年第1期14-17,共4页
Journal of Medical Forum
基金
河南省基础与前沿技术研究计划项目(122300410102)
关键词
河南省
黑色素瘤
临床特征
预后
Henan province
Malignant melanoma
Clinical characters
Prognosis
