摘要
目的:通过进行功能磁共振成像信号的局域一致性(Re Ho)分析及认知功能测试,研究儿童青少年双相障碍(Pediatric Bipolar Disorder,PBD)缓解相患者的静息态脑活动一致性情况,以及脑活动与认知功能变化的关系。方法:18例PBD缓解相患者和18例年龄、性别匹配的健康青少年参与功能磁共振数据采集,并对所有受试者进行临床检查和认知功能测试。计算磁共振成像信号的Re Ho指标,分析Re Ho结果与临床指标和认知测试的相关性。结果:与健康青少年相比,PBD缓解相患者的Stroop色词干扰测试评分显著降低,Re Ho数值在右侧小脑、左侧额下回、右侧后扣带回显著增加,在左侧顶上回及左侧辅助运动区显著降低。左侧额下回的Re Ho值与发病年龄及Stroop色词干扰测试评分显著负相关,与连线测试评分显著正相关,右侧后扣带回及左侧辅助运动区的Re Ho值分别与发病年龄呈显著负相关与正相关。结论:PBD缓解相患者存在小脑、额下回、后扣带回、顶上回及辅助运动区的神经活动一致性异常改变,且额下回的神经活动异常与PBD缓解相患者的发病年龄及认知功能受损有关。
Objective To investigate the homogeneity of resting-state neuronal activity in euthymic patients with pediatric bipolar disorder（PBD） and analyze the relationship between neuronal activity and cognitive function.Methods Eighteen euthymic patients with PBD and 18 age-and gender-matched healthy controls were enrolled in this study.All the participants underwent functional magnetic resonance imaging（f MRI） scanning,clinical examination and cognitive function tests.The f MRI data were collected to calculate regional homogeneity（ReHo） values,and the association of Re Ho values with the results of cognitive function tests and clinical findings were analyzed.Results Compared with healthy control subjects,the patients with PBD showed significantly decreased Stroop color-word test scores and significantly increased Re Ho values in the brain regions including the right cerebellum,left inferior frontal gyrus（IFG）,and right posterior cingulate cortex（PCC） but decreased Re Ho values in the left superior parietal gyrus（SPG） and left supplementary motor area（SMA）.Re Ho value in the left IFG was negatively correlated with the age of disease onset and Stroop color-word test scores,and positively with the results of trail making test.Re Ho value in the right PCC was negatively correlated while the value in the left SMA was positively correlated with the age of PBD onset.Conclusion Euthymic patients with PBD present with altered Re Ho of neuronal activity in the brain regions including the cerebellum,IFG,PCC,the SPG and SMA.The dysfunction of the left IFG is related with cognitive impairment and age of disease onset in patients with PBD.
出处
《中国医学物理学杂志》
CSCD
2018年第1期47-53,共7页
Chinese Journal of Medical Physics
基金
国家自然科学基金(81371531)
全军医学科技“十二五”科研重点基金(BWS11J063)
关键词
功能磁共振成像
局域一致性
青少年双相障碍
认知功能
functional magnetic resonance imaging
regional homogeneity
pediatric bipolar disorder
cognitive function
