摘要
目的 探讨头孢西丁钠联合康妇炎胶囊治疗盆腔炎的临床疗效及对炎性因子的影响.方法 采用随机数字表法将急性盆腔炎患者450例分为观察组和对照组,各225例.观察组采用头孢西丁钠联合康妇炎胶囊治疗,对照组采用头孢西丁钠治疗.比较两组治疗效果及治疗前后炎性因子的变化情况.结果 观察组治疗总有效率（93.3％比86.7％）及治愈率（66.7％比53.5％）均显著高于对照组,差异均有统计学意义（χ2=8.333、5.556,均P〈0.05）.治疗后,两组肿瘤坏死因子α（TNF-α）,白介素-6（IL-6）及C反应蛋白（CRP）均显著降低,且观察组TNF-α、IL-6、CRP改善情况明显优于对照组[（43.7±18.2）ng/L比（53.2±21.6）ng/L、（323.8±124.6）ng/L比（399.5±141.3）ng/L、（9.7±3.5）mg/L比（13.4±5.9）mg/L],差异均有统计学意义（t=7.865、5.783、4.517,均P〈0.05）.结论 在急性盆腔炎的治疗中,头孢西丁钠联合康妇炎胶囊能够明显提高治疗效果,改善炎性因子水平.
Objective To investigate the clinical effect of cefoxitin sodium combined with Kangfuyan capsules in the treatment of pelvic inflammatory disease and its influence on inflammatory cytokines .Methods According to the random number table method ,450 cases with chronic pelvic inflammatory disease were divided into the observation group and the control group ,225 cases in each group .The observation group was given cefoxitin sodium combined with Kangfuyan capsules treatment ,the control group received cefoxitin sodium therapy .The treatment effect and the changes of inflammatory cytokines before and after treatment were compared between the two groups .Results The total effective rate（93.3%vs.86.7%） and the cure rate（66.7%vs.53.5%） of the observation group were signif-icantly higher than those of the control group ,the differences were statistically significant （χ2 =8.333,5.556,all P〈0.05）.After treatment,the TNF-alpha,IL-6 and CRP levels in the two groups were significantly decreased ,which of the observation group were better than those of the control group [（43.7 ±18.2）ng/L vs.（53.2 ±21.6）ng/L, （323.8 ±124.6）ng/L vs.（399.5 ±141.3）ng/L,（9.7 ±3.5）mg/L vs.（13.4 ±5.9）mg/L],the differences were statistically significant（t=7.865,5.783,4.517,all P〈0.05）.Conclusion Cefoxitin sodium combined with Kang-fuyan capsule in the treatment of chronic pelvic inflammatory disease ,can significantly improve the treatment effect , improve the level of inflammatory cytokines .
出处
《中国基层医药》
CAS
2018年第2期201-204,共4页
Chinese Journal of Primary Medicine and Pharmacy
