摘要
目的:基于《伤寒论》探讨柴胡的应用规律,为临床应用提供借鉴。方法:系统整理《伤寒论》中含有柴胡的条文,采用SPSS20.0统计软件分析柴胡与相关因素之间关系。结果:经筛选,共纳入含柴胡方剂7首,占全方数目的比例为6.19%。对6首含有柴胡的汤剂进行二元相关性分析显示,柴胡单次用量与药味数密切相关,差异有统计学意义(P=0.004),而与用水量、剩余水量和服用次数无相关性(P=0.524,P=0.091,P=0.091)。柴胡单次用量平均为8.60 g,药味数平均为8.50味,柴胡单次用量是药味数的1.06倍,即柴胡的实际服用剂量为18.42~27.60 g(约等于18~28 g)。结论:从使用分布看柴胡主要用于少阳病,从量效关系可以发现柴胡在使用的方剂中均为主药,而且剂量及其配伍十分严格,临床上应根据"病皆与方相应者,乃服之"的指导原则灵活掌握柴胡的使用方法。
Objective： This study aims to provide reference for clinical application characteristics and rules by the analysis of the dose-response relationship of Chaihu（Radix Bupleuri）. Methods： We systematically arranged the previous articles containing the Chaihu（Radix Bupleuri） in Treatise on Febrile Diseases. Statistical analysis of the relationship between Chaihu（Radix Bupleuri） and other various factors was done by using SPSS 20.0. Results： After screening, 7 prescriptions concerning Chaihu（Radix Bupleuri） were selected, which accounting for 6.19% of the total prescriptions. By the bivariate correlations analysis, 6 of these decoctions showed a close relationship between the dose of Chaihu（Radix Bupleuri） and number of drugs, significantly（P =0.004）.However, it had no relationship with water consumption（P=0.524）, residual water（P=0.091） and frequency of use（P=0.091）. The average dose of Chaihu（Radix Bupleuri） was 8.60 g per times and the average number of drugs was 8.50, with a ratio of 1.06. The actual dose is 18.42-27.60 g（approximately equal to 18-28 g）. Conclusion： Chaihu（Radix Bupleuri） is mainly used for Shaoyang disease, and it is the key medicine in all of the prescriptions with strick usage of dose and combination. We must flexibly grasp the guiding principle of the Chaihu（Radix Bupleuri） in the clinical application.
出处
《中医药导报》
2018年第3期39-41,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
关键词
柴胡
伤寒论
量效关系
二元相关性分析
Chaihu （Radix Bupleuri）
treatise on Febrile Diseases
dose-response relationship
bivariate correlations analysis
