摘要
目的探讨上腹部多器官移植治疗上腹部多器官病变的长期疗效。方法回顾性分析2009－2017年间实施的31例简化式上腹部多器官移植受者的临床资料。结果术后对所有受者进行了13（2，28）个月的随访，术后1、3、5年累积存活率分别为82%、69%和69%。2例受者分别于术后15和18 d死于严重感染继发多器官功能衰竭，1例受者于术后37 d死于重症肺炎合并脓毒血症，1例受者于术后40 d死于移植物抗宿主病，1例受者于术后13个月死于急性髓系白血病，2例受者分别于术后18和26个月死于恶性肿瘤复发。随访过程中，均未发生胆道并发症及糖尿病复发。结论上腹部多器官移植治疗终末期肝病合并糖尿病患者安全、有效，受者可获得良好的长期存活及满意的生活质量。
Objective To investigate the long-term clinical efficacy of simplified multivisceral transplantation in patients with end-stage liver disease and type 2 diabetes. Methods The clinical data of 31 cases of simplified multivisceral transplantations between 2009 to 2017 were retrospectively analyzed. Results Median post-transplant follow-up was currently 13 ±26 （0-86） months. Two recipients died of multiple organ dysfunction system （MODS） followed by severe sepsis on postoperative day （POD） 15 and 18, respectively. One recipient died from severe pneumonia with pyemia on POD 37. One recipient died of graft versus host disease （GVHD） on POD 40. One recipient died from acute myelogenous leukemia. Two recipients died of tumor recurrence at postoperative month （POM） 9 and 26, respectively. No biliary complication or diabetes recurrence was observed during follow-up. Conclusion Donation after citizen＇s death is becoming the only organic source in China. Our results indicate that combined en-bloc liver-pancreas transplantation is technically feasible and leads to excellent long-term control of glucose metabolism and satisfactory quality of life in recipients with end-stage liver disease and diabetes mellitus.
作者
鞠卫强
李焯辉
张薇
郭志勇
韩明
王小平
陈茂根
马毅
王东平
朱晓峰
何晓顺
Ju Weiqiang , Li Zhuohui , Zhang Wei , Guo Zhiyong , Han Ming , Wang Xiaoping , Chen Maogen , Ma Yi, Wang Dongping, Zhu Xiaofeng, He Xiaoshun.(Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China)
出处
《中华器官移植杂志》
CAS
CSCD
2017年第12期714-718,共5页
Chinese Journal of Organ Transplantation
基金
广东省器官捐献与移植免疫重点实验室建设项目（2013A061401007）
关键词
多器官移植
肝移植
胰腺移植
十二指肠
糖尿病
2型
预后
Multivisceral transplantation
Liver transplantion
Pancreas transplantation
Duodenum
Diabetes mellitus, type 2
Prognosis
