摘要
目的对比分析应用盐酸利托君与硫酸镁治疗先兆早产的临床效果。方法 120例先兆早产患者,随机分成观察组与对照组,各60例。观察组采用盐酸利托君治疗,对照组采用硫酸镁治疗,对比两组治疗效果。结果观察组用药有效时间、延长孕期时间、新生儿体重、新生儿阿氏评分明显优于对照组,差异具有统计学意义(P<0.05)。观察组显效28例,有效30例,无效2例,治疗总有效率为96.67%;对照组显效21例,有效25例,无效14例,治疗总有效率为76.67%;观察组治疗总有效率明显高于对照组,差异有统计学意义(χ2=10.385,P<0.05)。观察组出现1例肌无力、1例胸闷、2例心悸、1例恶心,不良反应发生率为8.33%;对照组出现3例肌无力、3例胸闷、4例心悸、4例恶心,不良反应发生率为23.33%;观察组不良反应发生率明显低于对照组,差异有统计学意义(χ2=5.065,P<0.05)。结论对于先兆早产患者来说,采用盐酸利托君治疗效果优于硫酸镁,可在治疗中作为首选药物。
Objective To compare and analyze the clinical effect of ritodrine hydrochloride and magnesium sulfate in the treatment of threatened premature labor.Methods A total of 120 patients with threatened premature labor were randomly divided into observation group and control group,with 60 cases in each group.The observation group was treated with ritodrine hydrochloride,and the control group was treated with magnesium sulfate.The treatment effect in two groups was compared.Results The observation group had obviously better medication effective time,prolongation of pregnancy time,newborn weight,neonatal Apgar score than the control group,and their difference was statistically significant（P〈0.05）.The observation group had 28 excellent cases,30 effective cases and 2 ineffective cases,with total treatment effective rate as 96.67%,while the control group had 21 excellent cases,25 effective cases and 14 ineffective cases,with total treatment effective rate as 76.67%.The observation group had obviously higher total treatment effective rate than the control group,and the difference was statistically significant（χ~2=10.385,P〈0.05）.The observation group had 1 case of myasthenia,1 case of chest tightness,2 cases of palpitation,1 case of nausea,with incidence of adverse reactions as 8.33%,while the control group had 3 cases of myasthenia,3 cases of chest tightness,4 cases of palpitation,4 cases of nausea,with incidence of adverse reactions as 23.33%.The observation group had obviously lower incidence of adverse reactions than the control group,and the difference was statistically significant（χ~2=5.065,P〈0.05）.Conclusion Ritodrine hydrochloride shows better treatment effect for patients with threatened premature labor,and can be taken as the first choice in treatment.
出处
《中国现代药物应用》
2018年第5期96-98,共3页
Chinese Journal of Modern Drug Application
关键词
盐酸利托君
硫酸镁
先兆早产
Ritodrine hydrochloride
Magnesium sulfate
Threatened premature labor
