摘要
光动力学治疗(photodynamic therapy,PDT)是继手术、化疗和放疗之后肿瘤治疗的又一重要手段,其具有微创性、空间选择性和抗耐药性等优势,在临床上得到广泛应用。传统PDT采用单光子激发,激发波长远离光动力学治疗窗(650~950 nm),组织穿透能力弱并且容易造成光损伤。双光子PDT能够有效克服传统单光子PDT的固有缺陷,更好地发挥PDT在肿瘤治疗中的优势。光敏剂的研发一直是限制PDT应用的瓶颈,从第一代的血卟啉衍生物到目前具有靶向作用的第三代光敏剂,虽然在一定程度上满足了临床的需求,但仍然无法满足双光子PDT对光敏剂的要求。在双光子光敏剂研发过程中,钌多吡啶类配合物以其优良的光物理学性质一直备受关注,本文对近年来钌多吡啶类配合物在双光子PDT中的应用及研究进展进行了综述,以期为相关研究提供一定的参考。
Photodynamic therapy（PDT） has emerged as a more effective and promising treatment towards cancer therapy. PDT is a minimally invasive and spatially selective medical technique to destroy cancer cells without drug resistance, which has been increasingly applied in the clinical praxis alongside surgery, chemotherapy and radiotherapy. However, traditional PDTs use a high energy one-photon laser beam, which is far from the efficient optical window of mammalian tissue（650-950 nm）. Moreover, it has great limitations in the depth of penetration, and induces the undesired light toxicity. The development of photosensitizers has always been a bottleneck to the effective application of PDT in clinical practice. From the first generation of hematoporphyrin derivatives to the third-generation photosensitizers with tumor targeting ability, they meet the urgent clinical needs to some extent, but they still can not satisfy the requirements of two-photon PDT. Therefore, the development of photosensitizers, which are capable of two-photon activated PDT, has become a promising approach. Among the various two-photon absorption photosensitizers, ruthenium（Ⅱ） polypyridyl complexes have been recognized as excellent candidates due to their attractive photophysical properties. This review is prepared to summarize the recent achievements in the application of ruthenium（Ⅱ） polypyridyl complexes as photosensitizers for two-photon PDT, as well as to provide guidance for the design of two-photon activated photosensitizers in future research.
出处
《药学学报》
CAS
CSCD
北大核心
2018年第3期336-344,共9页
Acta Pharmaceutica Sinica
关键词
钌多吡啶类配合物
双光子激发
光敏剂
光动力学治疗
ruthenium （II） polypyridyl complex
two-photon excitation
photosensitizer
photodynamictherapy
