摘要
矢车菊素-3-O-葡萄糖苷是一种花色苷类物质,在自然界中广泛存在,含量高,该物质失去葡萄糖苷时为矢车菊素,是一种常见的花色素。大量流行病学研究表明,花色苷类物质具有预防骨质疏松症的作用,矢车菊素-3-O-葡萄糖苷及其花色素能够通过NF-κβ信号通路抑制破骨细胞增殖、分化和成熟,抑制多种破骨细胞标志性蛋白表达,但其调节NF-κβ信号通路的作用位点和机制目前尚不清楚。本文就矢车菊素和矢车菊素-3-O-葡萄糖苷对破骨细胞的作用及机制进行综述,希望能为骨质疏松症的防治提供研究思路。
Cyanidin-3-O-glucoside is a kind of anthocyanin,which is one of the most abundant and widely available anthocyanins in the world.The anthocyanidin part of it named cyanidin,without glucosidic group,is also widely available.A large number of epidemiological studies have shown that anthocyanins have the effect of preventing osteoporosis.Cyanidin-3-O-glucoside and its anthocyanidin can inhibit the proliferation,differentiation and maturation of osteoclasts by NF-κβ signaling pathway,and inhibit the expression of a variety of osteoclast markers,but its role in regulating NF-κβ signaling pathway and mechanism is not yet clear.This paper reviews the effects and mechanisms of cyanidin and cyanidin-3-O-glucoside on osteoclast,in hope of providing some research ideas for the prevention or treatment of osteoporosis.
出处
《国际药学研究杂志》
CSCD
北大核心
2017年第9期835-839,共5页
Journal of International Pharmaceutical Research
基金
辽宁省科学技术计划资助项目(20170540879)
沈阳医学院硕士研究生科技创新基金项目(Y20170604)
