摘要
目的研究乳腺癌患者术后复发时间与相关临床因素的关系。方法确定已复发的乳腺癌患者170例,应用Kaplan-Meier检验分析复发时间,并对相关影响因素进行分析。结果单因素分析显示,内分泌治疗、雌激素受体孕激素受体(estrogen receptor,progesterone receptor,ER,PR)状态、Ki-67、淋巴结转移个数与复发时间有关(P<0.05),应用Pearson相关分析分析提示,年龄、术前中性粒细胞/淋巴细胞比值(neutrophit-to-lymphocyte ratio,NLR)和血小板/淋巴细胞比值(platelet to lymphocyte ratio,PLR)与复发时间有关(P<0.0,5),最后用Cox多因素分析结果提示内分泌治疗、淋巴结转移、Ki-67是影响复发时间的独立预后因素(P<0.05)。结论根据患者的特征制定针对患者不同特征的个体化术后随访及辅助治疗策略,争取最大程度上预防乳腺癌的术后复发。
Objective To study the relationship between postoperative recurrence time and related clinical factors in patients with breast cancer. Methods The clinical data of 170 patients with recurrent breast cancer were analyzed retrospectively. The recurrence time and the related influencing factors were analyzed using Kaplan-Meier test. Results The one-way analysis of variance showed that endocrine therapy,estrogen receptor and progesterone receptor（ ERPR） status,Ki-67 and lymph node metastasis were related to the recurrence time（ P〈0. 05）. Pearson correlation analysis showed that age,neutrophil-to-lymphocyte ratio（ NLR） and platelet-to-lymphocyte（ PLR） were related to the recurrence time（ P〈0. 05）. Finally,Cox multivariate analysis showed that endocrine therapy,lymph node metastasis and Ki-67 were independent prognostic factors of relapse（ P〈0. 05）. Conclusion To develop personalized follow-up and adjuvant treatment strategy according to the characteristics of patients may prevent breast cancer from recurrence.
作者
何咏竞
孙国平
HE Yongjing;SUN Guoping.(Department of Oncology, First Affiliated Hospital, Anhui Medical University, Hefei 230000, Chin)
出处
《临床外科杂志》
2018年第1期35-38,共4页
Journal of Clinical Surgery
关键词
乳腺癌
复发时间
影响因素
Breast cancer
Recurrence time
Influencing factor
