摘要
目的分析川崎病(KD)并发冠状动脉病变(CAL)的相关危险因素。方法回顾性分析353例KD患儿临床资料;其中,并发CAL(CAL组)113例,无CAL(NCAL组)240例。分析KD患儿CAL发生相关危险因素。结果单因素分析显示,CAL组男性患儿和年龄≤2岁患儿比例高于NCAL组(P<0.05)。CAL组血红蛋白(Hb)水平低于NCAL组,但C反应蛋白(CRP)>50mg/L比例高于NCAL组(P<0.01)。非条件二分类Logistic回归分析显示,男性[OR=1.861,95%CI(1.142~3.301)]、Hb水平降低[OR=0.976,95%CI(0.953~1.000)]和CRP>50mg/L[OR=1.721,95%CI(1.029~2.880)]是KD患儿并发CAL的独立危险因素(P<0.05)。结论男性患儿、Hb水平降低及CRP>50mg/L是KD患儿发生CAL的独立危险因素。
Objective To analyze the related risk factors for coronary artery lesion（CAL） in children with Kawasaki disease（KD）. Methods Clinical data of 353 KD children were retrospectively analyzed,who were assigned into two groups of CAL（with CAL, 113 cases） and NCAL（without CAL, 240 cases）. The related risk factors for CAL in KD children were analyzed. Results Univariate analysis showed that the proportions of male gender and age more than 2 years old were higher in CAL group than those in NCAL group（P〈0. 05）. Hemoglobin（Hh） level was lower, but the proportion of C reactive protein（CRP）〉50 mg/L was higher, in group CAL than those in group NCAL（P〈0. 01）. Binary Logistic regression analysis showed that the male gender[OR=1.86], 95%CI （1.142-3. 301）],lower level of Hb[OR=0. 976,95%CI（0. 953-1. 000）] and CRP〉50 mg/L[OR= 1. 721,95% CI（1.029-2. 880）] were the independent risk factors for CAL in children with KD （P〈0. 05）. Coneluslon Male gender,lower level of Hb and CRP〉50 rng/L are the independent risk factors for CAL in children with KD.
出处
《江苏医药》
CAS
2018年第2期151-153,共3页
Jiangsu Medical Journal
基金
江苏省中医药局科技项目(YB2017096)
苏州市"科教兴卫"青年科技项目(KJXW2016017)
关键词
川崎病
冠状动脉病变
Kawasaki disease
Coronary artery lesion
