摘要
目的探讨MRS定量分析用于监测儿童惊厥性脑损伤临床效果。方法选择2014年12月—2016年12月收治的150例惊厥性脑损伤儿童患者为研究对象,均给予头颅MRI+MRS定量检查,检测患者双侧海马区、对照区,观察评估Cr、Cho、NAA等峰下面积,并核算出Cho/NAA值。结果经诊断显示为热性惊厥者115例,癫痫者22例,脑炎者13例,正常者25例(诊断为鼻窦炎者15例,中枢性性早熟者10例);非正常组显示Cho/NAA值明显升高,提示可能存在轴索或神经元损伤,细胞膜代谢异常增高等表现;且NAA下降,提示存在轴索或神经元损伤;其中未见异常者15例。正常组则均显示无明显异常征象;男性患儿惊厥发生中出现MRI波谱异常者为74.07%,明显高于女性患儿55.07%,差异具有统计学意义(P<0.05)。结论将MRS定量分析应用于儿童惊厥性脑损伤中确有较好效果,以该项技术对分子水平表达优势,可早期发现惊厥后患儿神经元或轴索存在的损伤。
Objective To analyze the clinical effect of MRS quantitative analysis for monitoring children＇s convulsive brain damage. Methods 150 cases of children with convulsive brain injury from December 2014 to December 2016 were selected as subjects. All patients were given quantitative MRI ＋ MRS examination. The hippocampal area and control area were detected. The area under peak area such as Cr, Cho and NAA were observed and evaluated, and the Cho/NAA value was calculated. Results After diagnosis showed febrile convulsion in 115 cases, 22 cases of epilepsy, 13 cases of encephalitis, 25 cases of normal persons （ diagnosed sinusitis in 15 cases, 10 cases of central precocious puberty） ; Non positive Often group shows that the value of Cho/NAA was significantly increased, suggesting axonal or neuronal damage, cell membrane metabolism increased; And NAA decreased, suggesting the presence of axonal or neuronal injury; 15 cases were abnormal. The normal group showed no obvious abnormal signs; Male convulsion occurred in MRI abnormal spectrum 74. 07% , was significantly higher than that of female children with 55.07% the difference was statistically significant （ P 〈 0. 05 ）. Conclusion MRS quantitative analysis is applied to children brain injury has good effect on the technology. The advantage of molecular level expression can early detect the damage of neurons or axons in children after seizures.
出处
《现代医院》
2018年第2期305-307,共3页
Modern Hospitals
关键词
MRS定量分析
儿童
惊厥性脑损伤
效果
MRS Quantitative Analysis
Children
Convulsive Brain Injury
Effect
