摘要
目的探讨尘肺病患者细颗粒物暴露量与动脉血管僵硬度的关系,比较不同细颗粒物暴露量对动脉僵硬度的影响。方法采用横断面研究,选择开滦煤矿已确诊尘肺病的患者为研究对象,根据尘肺患者累积粉尘暴露量(CDE)四分位数将研究对象分为第1分位组(CDE<877 mg/m3-y)、第2分位组(877≤CDE≤1 105 mg/m3-y)、第3分位组(1 105<CDE≤1 320mg/m3-y)、第4分位组(CDE>1 320 mg/m3-y)。采用多因素logistic回归分析,比较不同CDE对臂踝脉搏波传导速度(ba PWV)的影响。结果 813例研究对象均为男性,4组平均年龄分别为62.09、61.32、65.57、72.47岁,ba PWV分别为1 692.51、1 689.25、1 789.96和1 915.55 cm/s。4组ba PWV≥1 725 cm/s的检出率分别为40.3%、44.1%、49.5%和68.6%。偏相关分析显示,CDE与ba PWV呈正相关(P<0.05);校正年龄、心率(HR)、体质指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、糖尿病患病率、高血压患病率、吸烟率等因素后,与CDE第1分位组比较,第4分位组ba PWV≥1 725 cm/s的风险增加2.61倍(OR=2.61)。结论尘肺患者CDE与ba PWV呈正相关,是动脉硬化的独立危险因素。
Objective To investigate the relationship between cumulative silica dust exposure （CDE） and brachial-ankle pulse wave velocity （baPWV） , and compare the effects of different exposure levels of fine particulate matter on arterial stiffness. Methods Using cross-sectional study design, patients with pneumoconiosis in Kailuan Colliery were selected as the study subjects. The subjects were divided into four groups according to CDE, quartile 1 （ CDE 〈 877 mg/m3 - y）, quartile 2 （ 877 ≤ CDE ≤ 1 105 mg/m3 - y）, quartile 3 （ 1 105 〈 CDE ≤ 1 320 mg/ m3 - y） , quartile 4 （ CDE 〉 1 320 mg/m3 - y）. Multivariate logistic regression was used to compare the effects of different CDE on the baPWV. Results All of the 813 subjects were male. The average age of the four groups was 62.09, 61.32, 65.57, and 72.47 years, re- spectively. The baPWVs in the 4 groups were 1 692.51, 1 689.25, 1 789.96, and 1 915.55 cm/s, respectively. The detection rates of baPWVs beyond 1 725 cm/s in the four groups were 40.3% , 44. 1% , 49.5% , and 68.6% , respectively. Partial correlation analysis showed that CDE was positively correlated with baPWV （ P 〈 0.05 ）. After adjusting for age, heart rate, BMI, TC, TG, LDL-C, HDL-C, diabetes mellitus, hypertension, and smoking,the risk of baPWV greater than 1 725 cm/s increased （OR = 2.61 ） in the fourth subgroup compared with the CDE quartile 1 group. Conclusion CDE in patients with pneumoconiosis was positively correlated with baPWV and an independent risk factor for arteriosclerosis.
出处
《华南预防医学》
2018年第1期12-16,共5页
South China Journal of Preventive Medicine
关键词
尘肺
粉尘
暴露量
踝臂脉搏波传导速度
因素分析
统计学
Pneumoconiosis
Dust
Exposure dose
Brachial-ankle pulse wave velocity
Factor analysis, statistical
