摘要
目的:了解安徽医科大学第一附属医院(以下简称"我院")生殖医学中心门诊医嘱用药情况,探讨超说明书用药的合理性及相关对策,为临床合理用药提供参考。方法:回顾性分析2016年我院生殖医学中心门诊随机抽取的用药医嘱77 776条,以药品说明书为依据,参照《处方管理办法》,对其中的超说明书用药医嘱进行统计分析,并根据相关诊疗规范、临床指南和专家共识、循证医学或文献探讨超说明书用药医嘱的合理性。结果:77 776条用药医嘱中,超说明书用药医嘱33 239条(占42.74%);超说明书用药类型主要包括超适应证、超剂量和(或)超频次、超给药途径和超禁忌证等;超说明书应用黄体酮注射液的医嘱共13 272条(占超说明书用药医嘱的39.93%),多为超剂量用药。结论:2016年我院生殖医学中心门诊超说明书用药情况比较普遍。根据相关药物使用说明、既往研究报告、相关专家共识及循证医学证据分析可见,大部分超说明书用药基本合理,但仍存在一定的用药风险。建议相关部门制定有效措施,保障临床合理用药。
OBJECTIVE： To investigate the drug application of outpatient medical orders in reproductive medicine center of department of gynecology and obstetrics in the First Affiliated Hospital of Anhui Medical University（ hereinafter referred to as ＂our hospital ＂）, to discuss the rationality of off-label medication and related countermeasures,so as to provide references for clinical rational medication. METHODS： 77 776 outpatients medication orders in reproductive medicine center of department of gynecology and obstetrics in our hospital in 2016 were randomly extracted and retrospectively analyzed,off-label medical orders therein were collected and analyzed on the basis of dispensatory and relevant regulations in ＂Prescription Administrant Policy＂,and the rationality of off-label medication orders were discussed according to relevant rules of diagnosis and treatment,clinical guidelines and consensus from specialists,evidence-based medicine or related literatures. RESULTS： Of 77 776 medication orders,there were 33 239 off-label medication orders（ 42. 74%）; types of off-label medication orders mainly including overindication,overdose and（ or） overfrequency,off-route of administration and off-contraindication,etc; there were 13 272 off-label medication orders（ 39. 93%） with application of progesterone injection,mostly were overdose medication. CONCLUSIONS： Off-label medication in outpatient of reproductive medicine center of department of gynecology and obstetrics is slightly prevalent in our hospital in 2016. According to instructions of relevant drugs,previous research reports and consensus from related specialists,most off-label medications are basically rational,however,there is still a certain medication risk. Effective measures are suggested to be formulated to ensure clinical rational medication.
出处
《中国医院用药评价与分析》
2018年第1期113-116,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
安徽医科大学第一附属医院国家自然基金培育基金(No.3101005002547)
关键词
超说明书
生殖医学
合理用药
Off-label
Reproductive medicine
Rational drug application
