摘要
目的：探寻热毒宁吸入溶液递送剂量信息和气溶胶粒径信息之间的相关性。方法：选择绿原酸、栀子苷为指标成分,采用呼吸模拟器测定递送剂量均一性,利用新一代微粒撞击收集仪测定空气动力学粒径分布,运用实时喷雾粒度分析仪测定实时喷雾粒径分布,将递送剂量信息组与粒径信息组进行相关性分析。结果：两变量组组内多数原始变量具有较强的相关性,原始变量组间相关性优劣不一。经典型相关分析后,提取出2对相关性显著的典型变量,其相关系数分别为0.998和0.955。递送剂量组接近90%的信息和粒径组超过70%的信息能够被这2对典型变量所概括。结论：对于热毒宁吸入溶液递送剂量信息和气溶胶粒径信息,原始变量组内相关性良好,组间相关性参差不齐。相比原始变量,典型变量呈现出了较好的组间相关性,表明递送剂量信息和粒径信息有一定的相关性,且提取出的2对典型变量能够较好的预测两组内的原始变量。
Objective： To find out the correlation between information groups of delivery dose and aerosol particle size of Reduning inhalation solution.Method： Taking chlorogenic acid and geniposide as index components,the delivery dose uniformity was determined by a breathing simulator and the aerodynamic particle size distribution was measured by a new generation of particle impactor.Realtime particle size distribution was monitored by a laser diffractometers.The correlation analysis between information groups of delivery dose and aerosol particle size was investigated.Result： Most primitive variables of two sets had good intra-class correlations,but the inter-group correlation was not as good as intra-class correlation.After the canonical correlation analysis,two pairs of canonical variables had significant correlations with correlation coefficients being 0.998 and 0.955,respectively.Almost 90% information of delivery dose group and more than 70% information of particle size group could be elucidated by the two pairs of canonical variables.Conclusion： There is a good intra-class correlation for each of delivery dose group and particle size group,but the correlation between two sets is not so good.Canonical variables perform better inter-group correlation by comparing with original variables,indicating there is a certain correlation between delivery dose and aerosol particle size of Reduning inhalation solution.Furthermore,original variables of these two sets can be well predicted by the two pairs of canonical variables extracted.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2018年第4期1-7,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
江苏康缘药业有限公司与中国中医科学院中药研究所共建项目
关键词
热毒宁吸入溶液
体外吸入性能
典型相关分析
绿原酸
栀子苷
冗余分析
标准化处理
Reduning inhalation solution
in vitro inhalation performance
canonical correlation analysis
chlorogenic acid
geniposide
redundancy analysis
standardized processing
