摘要
目的探讨α-硫辛酸联合依帕司他对糖尿病胃轻瘫的疗效及其对自由基的影响。方法选取达州市中西医结合医院内分泌科2014年9月至2016年9月期间收治的90例糖尿病胃轻瘫患者作为研究对象,按照随机数表法分为α-硫辛酸组、依帕司他组和联合用药组,每组30例,分别行单用α-硫辛酸、单用依帕司他及联合用药治疗,疗程均为3周。观察三组患者治疗前后血清中超氧化物歧化酶(SOD)、丙二醛(MDA)、胃动素、胃泌素含量变化,评价患者治疗前后临床症状及治疗效果。结果与治疗前相比,治疗后三组患者血清SOD含量升高,MDA含量下降,差异均有统计学意义(P<0.05);联合用药组患者血清中SOD含量明显高于α-硫辛酸组或依帕司他组,MDA含量明显低于α-硫辛酸组或依帕司他组,差异均有统计学意义(P<0.05);治疗后,三组患者血清中胃动素及胃泌素含量明显高于治疗前,联合用药组患者血清中胃动素及胃泌素含量明显高于α-硫辛酸组或依帕司他组,差异均有统计学意义(P<0.05);治疗后,三组患者临床症状均有缓解,但联合用药组患者治疗后临床症状评分明显低于α-硫辛酸组或依帕司他组,差异均有统计学意义(P<0.05);联合用药组患者的临床治疗总有效率为86.67%,明显优于α-硫辛酸的70.00%和依帕司他的63.33%,差异均有统计学意义(P<0.05)。结论α-硫辛酸联合依帕司他治疗糖尿病胃轻瘫可有效减轻氧化应激对患者的损伤,同时促进胃动素及胃泌素的分泌,改善临床症状,值得临床推广应用。
Objective To explore the curative effect of α-lipoic acid combined with epaltestat in the treatment of diabetic gastroparesis and their influence on free radical. Methods From September 2014 to September 2016, 90 patients of diabetic gastroparesis admitted in Department of Endocrinology, Dazhou Hospital of Integrated Traditional Chinese and Western Medicine were randomly divided into α-lipoic acid group（n=30）, epalrestat group（n=30）, combination group（n=30）, which were treated with α-lipoic acid, epalrestat, and α-lipoic acid combined with epaltestat, respectively. The course of treatment was 3 weeks. The changes of serum superoxide dismutase（SOD）, malondialdehyde（MDA）, motilin and gastrin levels in the three groups before and after treatment were observed, and the clinical symptoms and treatment effect before and after treatment were evaluated. Results Compared with before treatment, the levels of serum SOD after treatment were significantly increased in the three groups, while MDA levels were significantly decreased（P0.05）. Serum SOD level in combination group was significantly higher than that of α-lipoic acid group or epalrestat group（P0.05）, while the level of MDA was significantly lower than that of α-lipoic acid group or epalrestat group（P0.05）. After treatment, serum motilin and gastrin content in the three groups were significantly higher than those before treatment（P0.05）, and motilin and gastrin levels were significantly higher in combination group than in α-lipoic acid group or epalrestat group（P0.05）. After treatment, clinical symptoms were all alleviated in the three groups,but the clinical symptom score after treatment in combination group was significantly lower than that of α-lipoic acid group or epalrestat group（P0.05）. The total effective rate of the combination group was 86.67%, significantly higher than of 70.00% in α-lipoic acid group and 63.33% in epalrestat group（P0.05）. Conclusion α-lipoic acid combined with epalrestat in treatment
出处
《海南医学》
CAS
2018年第4期455-458,共4页
Hainan Medical Journal
基金
四川省科技支撑计划(编号:2014SZ4677)
关键词
Α-硫辛酸
依帕司他
糖尿病胃轻瘫
自由基
疗效
α-lipoic acid
Epaltestat
Diabetic gastroparesis
Free radical
Curative effect
