摘要
目的探讨影像学表现阴性的颞叶局灶性皮质发育不良(FCD)的诊断和定位方法,为手术治疗提供依据。方法联合应用视频脑电图和弥散张量成像检查,通过视频脑电图特异表现,联合应用表观弥散系数值、部分各向异性值、弥散张量纤维束成像,诊断和定位影像学表现阴性的颞叶FCD。结果 FCD区域的视频脑电图主要表现为棘波、尖波和阵发性或节律性的棘波活动,慢波出现较少或没有。FCD区域的表观弥散系数值较对侧显著升高,而部分各向异性值明显低于对侧,差异有统计学意义(P<0.05)。全部38例患者依据视频脑电图和弥散张量成像确定的颞叶FCD范围行手术切除。病理回报为FCDⅠA型11例,ⅠB型13例,ⅠC型10例,ⅡA型4例。术后随访12~26月,本组患者Engel'sⅠa级7例,Ⅰb级16例,Ⅱ级10例,Ⅲ5级。结论联合应用视频脑电图和弥散张量成像技术可以准确定性、定位影像学检查阴性的颞叶FCD,为精确切除致痫灶,提高颞叶癫痫控制率提供保障。
Objective To explore the diagnosis and localization of focal cortical dysplasia type I, and provide the basis for the surgical treatment. Methods Video EEG with combination of DTI were performed.VEEG specific performance, ADC value, fractional anisotropy, diffusion tensor imaging were used to diagnose and locate FCD I type with negative imaging . Results The apparent diffusion coefficient of FCD region was significantly higher than contralateral area.Fractional anisotropy was significantly lower than contralateral area （P〈0.05）. All patients were performed with resection based on FCD position and range, which determined by VEEG and DTI . The pathological return was type of FCD Ⅰ. The patients were followed up for 12-26 months,with 7 cases of Engel＇s grade Ⅰa, 28 cases of grade Ⅰb, 16 cases of gradeⅡ. Conclusion VEEG combined with DTI technology can accurately define and locate FCDⅠtype with negative imaging.It can provide protection for the precise excision of epileptogenic focus and improve seizure control.
出处
《分子影像学杂志》
2018年第1期23-26,共4页
Journal of Molecular Imaging
关键词
视频脑电图
弥散张量成像
局灶性皮质发育不良
诊断
定位
video electroencephalogram
diffusion tmsor imaging
focal cortical dysplasias
diagnosis
location
