摘要
目的探讨清开灵注射液联合抗菌药物治疗老年肺气肿合并肺部感染患者的临床效果。方法选取2014年1月至2016年1月在我院诊治的老年肺气肿合并肺部感染患者120例，应用SAS10．0软件生成随机数字分为清开灵组、常规组各60例，两组均给予抗菌药物、吸氧、促排痰等基础治疗，清开灵组加用清开灵注射液，一个疗程后观察临床效果差异（7d为1个疗程）。结果治疗7d后，清开灵组患者的IL-2、IL-6、IL-8、肿瘤坏死因子α（TNF-α）及内皮索（ET）的水平均低于常规组患者（P〈0．05），清开灵组患者的咳嗽、痰液量、痰液黏稠度、气促、肺部啰音评分均低于常规组患者（P〈0．05）；清开灵组患者的PaCO2低于常规组患者、PaO2水平高于常规组（P〈0．05）。结论清开灵注射液联合抗菌药物治疗老年肺气肿合并肺部感染有助于缓解临床症状，降低炎症反应水平。
Objective To study Qingkailing injection combined with antibiotics in the treatment of the clinical effect of patients with senile emphysema complicated with pulmonary infection. Methods 120 patients from January 2014 to January 2016 in our hospital diagnosis and treatment of senile emphysema complicated with pulmonary infection, using SAS10. 0 software to generate randomly divided into Qingkailing group, normal group 60 cases, two groups were given antibiotics, oxygen inhalation, promoting expectoration and other basic treatment. Qingkailing group combined with Qingkailing injection. We observed the clinical effect of a difference after treatment （7 days for 1 courses）.Results After 7 days of treatment, Qingkailing group IL-2, IL-6, IL-8, TNF-α and ET levels were lower than the normal group （ P 〈 0.05）, Qingkailing group in patients with cough, sputum volume, sputum viscosity, shortness of breath, pulmonary rales were significantly lower than those of the routine group （ P d0.05）. The level of PaO2 in Qingkailing group was lower than that in the conventional group, higher than that in the conventional group （ P 〈0,05）. Conclusions Qingkailing injection combined with antibiotics in the treatment of senile emphysema complicated with pulmonary infection helps relieve clinical symptoms, reduce the level of inflammatory reaction.
出处
《国际呼吸杂志》
2018年第3期211-214,共4页
International Journal of Respiration
关键词
清开灵
老年
肺气肿
肺部感染
Qingkailing
Elderly
Pulmonary emphysema
Pulmonary infection
