摘要
目的研究阿戈美拉汀对首发老年抑郁症的疗效。方法选取首发老年抑郁症116例,随机分为观察组和对照组,每组58例。观察组给予阿戈美拉汀治疗,对照组给予舍曲林治疗。对两组疗效、睡眠改善及不良反应进行比较。结果观察组自第1周末起、对照组自第2周末起HAMD、PSQI评分显著下降(P<0.01)。第1、2、4、8周末观察组HAMD评分显著低于对照组(P<0.05),第4、8周末观察组PSQI评分明显低于对照组(P<0.05)。观察组服药期间不良反应发生率明显低于对照组(P<0.05)。结论阿戈美拉汀与舍曲林治疗老年首发抑郁症均有效,但阿戈美拉汀起效快,不良反应少,改善失眠症状更优。
Objective To investigate the curative effect of agomelatine on patients with first-episode senile depression. Methods One hundred and sixteen elderly patients with first-episode depression were randomly divided into the observation group and the control group, 58 cases in each group. The patients of the observation group were given agomelatine and the patients of the control group were given sertralin. The treatment effect, sleep improvement and ad- verse reactions of the two groups were compared. Results The scores of HAMD and PSQI in the observation group after one week treatment and the scores in the control group after two week treatment decreased significantly （P 〈 0.01 ） . At the end of 1th , 2th, 4th and 8th week, the HAMD scores of observation group were significantly lower than control group. At the end of 4th, 8th week, the PSQI scores of observation group were lower than control group significantly （P 〈 0.05 ） . The incidence rate of side effect in observation group was lower than that in control group （ P〈0.05 ） . Conclusion Both agomelatine and sertralin are effective in the treatment of elderly patients with first-episode depression, but agomelatine is earlier response, less adverse reaction and improving insomnia better.
出处
《国际精神病学杂志》
2018年第1期65-67,共3页
Journal Of International Psychiatry
