摘要
目的:考察注射用红花黄色素与果糖注射液,转化糖注射液,转化糖电解质注射液,葡糖糖氯化钠注射液,5%葡萄糖注射液,10%葡萄糖注射液及0.9%氯化钠注射液配伍的稳定性考察。方法:模拟临床用药浓度,在室温(25±1)℃下放置8h,以氯化钠配伍液为对照组,分别观察各种配伍液外观,不溶性微粒数量及pH变化,运用高效液相色谱法测定注射用红花黄色素在不同配伍液中的含量变化。结果:注射用红花黄色素与7种输液配伍后在8h内外观,pH和含量均无明显变化,不溶性微粒数符合中国药典2015年版规定。结论:注射用红花黄色素与7种输液配伍在8 h内稳定。
Objective： To study the stability of safflower yellow for injection respectively mixed with fructose injection,invert sugar injection,invert sugar electrolyte injection,glucose and sodium chloride injection,5% glucose injection,10% glucose injection and 0. 9% sodium chloride injection. Methods： The physical appearance,number of particles and pH value were observed at room temperature after mixing safflower yellow respectively with above injections for 8 hours at the same concentration as that in clinical use. The content of safflower yellow was determined by high performance liquid chromatography（ HPLC）. Results： There was no significant difference in appearance,p H or safflower yellow content after the mixing,and the number of insolubility particles met the requirement in Chinese Pharmacopeia（ 2015 edition）. Conclusion： Safflower yellow for injection is stable after dissolved in the 7 varieties of infusions in 8 h.
出处
《中国药师》
CAS
2018年第2期371-373,共3页
China Pharmacist
