摘要
目的:调查儿童医院住院患者高风险片剂的使用剂量及频率分布,研究现有高风险药品规格是否满足儿科临床需求。方法:调取2014~2016年全年上海儿童医学中心住院患者高风险片剂全部处方,分析各药品各剂量的使用频率,依据频率判断现有规格是否满足临床实际需求。对不满足临床实际需求的药品给出建议新增规格,依据建议的规格重新核算3年间全部处方,给出核算后的使用频率,以此来评价建议新增的规格是否贴合临床实际需求。结果:该医院有5种高风险口服片剂,甲氨蝶呤片和维A酸片现有规格符合临床实际需求。巯嘌呤片需要新增12.5 mg和17 mg两种规格品种,华法林钠片需要新增1.25 mg品种。羟基脲片250 mg和华法林钠片1 mg品种建议引入儿童医院。结论:现有高风险口服片剂剂量规格并不能完全满足临床需求,需要进行剂量调整。
Objective： To analyze the dosage distribution and the frequency of each dosage of high-risk tablets in the hospitalized patients in a children＇s hospital,and study whether the existing specifications of high-risk tablets meet the pediatrics clinical needs.Methods： All the prescriptions including high risk tablets were analyzed from 2014 to 2016 in Shanghai children＇s medical center.The frequency of every dosage of every drug was analyzed,and the current specifications were judged according to the frequency. New specifications were proposed when the existing specifications did not match the clinical needs. The new frequency of the proposed specifications was re-accounted for all the three-year prescriptions in order to evaluate whether the proposed new specifications met the clinical needs. Results： Among the five kinds of high-risk oral tablets,methotrexate tablets and vitamin A acid tablets were in accordance with the actual clinical requirements. Mercaptopurine tablets should add two specifications including 12. 5 mg and 17 mg,and warfarin sodium tablets should add one specification（ 1. 25 mg）. Hydroxyurea tablets（ 250 mg） and warfarin sodium tablets（ 1 mg） were recommended used in the children＇s hospital. Conclusion： The existing specifications of high-risk oral tablets can＇t fully meet the clinical needs,therefore,specifications still needs to be adjusted.
出处
《中国药师》
CAS
2018年第2期257-260,共4页
China Pharmacist
基金
九三学社上海市委参政议政课题(编号:zb064)
上海交通大学文理交叉专项基金(编号:17JCYB11)
关键词
高风险
片剂
规格
分剂量
儿童
High-risk
Tablets
Specification
Sub-dose
Children
