摘要
目的在重庆市3家医院研究阿米替林预防性治疗偏头痛的效果。方法该研究从2014年9月—2016年12月在重庆3家医院中筛选了72例伴有抑郁的偏头痛患者,使用阿米替林治疗。对患者治疗前后的疼痛评分,疼痛次数,抑郁量表,脑电图进行统计学分析。结果最终68例患者完成了临床实验。经过阿米替林的治疗,患者的疼痛评分从(6±2.4)分,变为(2±1.5)分,(P<0.05),患者的疼痛次数从(8±3.5)次/月变为(3±2.1)次/月(P<0.05),有12例患者的抑郁症状完全缓解(P<0.05)。治疗前68例患者有30例患者(44.1%)出现脑电图的变化,治疗后有29例患者(42.6%)出现脑电图的变化。患者治疗后与治疗前相比,脑电图没有明显变化(P>0.05)。结论阿米替林25mg/d连续使用3月可以有效的治疗偏头痛。
Objective This paper tries to study the amitriptyline ’s treatment of migraine in three Chongqing hospitals. Methods In this study, 72 patients with migraine and depression were screened in three hospitals in Chongqing from September 2014 to December2016, using amitriptyline treatment. The pain scores, the times of pain, the depression scale, and the EEG were analyzed statistically before and after treatment. Results 68 patients were completed in the test. After the amitriptyline treatment, the VAS score decreased from（6±2.4）points to（2±1.5）points（P〈0.05）, the times of pain decreased from（8 ±3.5）times per month to（3±2.1）times per month（P〈0.05）, and 12 patients had been completely remission of depression（P〈0.05）; 30 patients（44.1%） had EEG changes in 68 patients before treatment, and 29 patients（42.6%） had EEG changes after treatment, but there was no significant difference in the EEG changes（P〉0.05）. Conclusion The treatment of amitriptyline of 25 mg per day for continuous 3 months is effective for migraine.
出处
《世界复合医学》
2017年第4期74-76,共3页
World Journal of Complex Medicine
基金
重庆市教委项目资助(KJ1500234)
重庆市渝中区科委项目资助(X4348)
关键词
阿米替林
偏头痛
抑郁
Amitriptyline
Migraine
Depression
