摘要
巨噬细胞作为肝脏微环境的重要组成部分，在消化系统肿瘤肝转移的发生、发展中起重要作用。一方面巨噬细胞与肝窦内皮细胞等构成肝脏第一道防线，能够吞噬进入肝血窦的循环肿瘤细胞或促进其凋亡，或者发挥细胞毒性作用从而抑制肝转移的发生。另一方面，巨噬细胞与循环肿瘤细胞结合以后活化，释放肝细胞生长因子等多种细胞因子，刺激肿瘤细胞的增殖进而促进肝转移的发生。针对巨噬细胞开展肿瘤免疫治疗，或许可以为消化系统肿瘤肝转移的防治提供新的思路。
Maerophagses are important components of the liver microenvironment, and play an essential role in the occurrence and development of liver metastasis of digestive system malignancies. Macrophages and liver sinusoidal endothelial cells constitute the first defense line of the liver, which can rapidly recognize and arrest the circulating tumor cells invading into the liver sinusoidal, by phagocytosis or promoting their apoptosis, thus play a cytotoxic effect to inhibit the occurrence of liver metastases. On the other hand, macrophages can combine to the circulating tumor cells and be activated. As a result, hepatocyte growth factor and other cyto- kines were released, which significantly promoted the proliferation of tumors cells, and thus promoting liver metastases. It may provide a new idea in preventing and treating liver metastasis of digestive system malignancies by targeting maerophages during tumor immunotherapy.
出处
《国际肿瘤学杂志》
CAS
2017年第12期940-943,共4页
Journal of International Oncology
基金
湖南省卫生计生委2017年度科研计划（B2017101）
关键词
巨噬细胞
肿瘤转移
肿瘤微环境
Macrophages
Neoplasm metastasis
Tumor microenvironment
