摘要
目的探讨联合应用生长抑素和奥美拉唑对高龄重症急性胰腺炎患者早期腹内高压及肠道黏膜屏障功能的影响。方法选取2013月1月-2017年2月诊治的高龄重症胰腺炎患者76例,按照数字表法随机分为对照组和研究组各38例;对照组患者给予基础治疗,研究组在对照组的基础上给予生长抑素+奥美拉唑进行治疗。结果 (1)治疗后研究组总有效率明显高于对照组,P<0.05差异具有统计学意义;(2)经治疗后研究组患者的腹内高压、腹痛腹胀及肠道恢复时间明显优于对照组,P<0.05差异具有统计学意义;(3)研究组腹内高、D-乳酸及二胺氧化酶水平明显低于对照组,P<0.05差异具有统计学意义。结论生长抑素联合奥美拉唑早期应用在高龄重症急性胰腺炎患者,有助于降低腹内高压水平及改善肠道黏膜屏障功能,值得临床参考。
Objective To investigate the effects of combination of growth statin and omeprazole on the function of early abdominal hypertension and intestinal mucosal barrier in patients with advanced severe pancreatitis. Methods 76 patients with severe acute pancreatitis were selected from January to February 2017 in our hospital, and 38 cases were randomly divided into the control group and the study group according to the digital table method. The control group was given basic treatment, and the group was treated with somatostatin plus omeprazole based on the control group. Results After treatment, the total effective rate of the group was significantly higher than that in the control group, and P 〈 0. 05 was statistically significant. After treatment, the abdominal hypertension, abdominal distention and intestinal recov- ery time of the patients in the group were significantly better than that in the control group, and P 〈 0. 05 was statistically significant. The level of intra - abdominal high, d - lactic acid and diamine oxidase was significantly lower than that in the control group, and P 〈 0. 05 was statistically significant. Conclusions To discuss the early application of somatosta- tin combined with omeprazole in advanced patients with severe acute pancreatitis can help reduce intra- abdominal high pressure and improve the function of intestinal mucosal barrier, which is worthy of clinical reference.
出处
《航空航天医学杂志》
2017年第12期1440-1442,共3页
Journal of Aerospace medicine
关键词
生长抑素
奥美拉唑
高龄重症急性胰腺炎
早期应用
腹内高压
肠道黏膜屏障功能
somatostatin
Omeprazole
Acute pancreatitis of advanced age
Early application
Abdominal hyperten-sion
Intestinal mucosal barrier function
