摘要
腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是调节细胞能量代谢的关键酶。近几年深入研究发现其具有促胰岛β细胞凋亡的作用,可通过线粒体凋亡途径、内质网应激凋亡途径及哺乳动物m TOR通路等诱导细胞凋亡。本文就AMPK促进胰岛β细胞凋亡的作用及可能的机制作一简要综述。
AMP-activated protein kinase（AMPK） is a key enzyme in the regulation of cellular energy metabolism. Recent studies have also found that AMPK may promote apoptosis of islet beta cells. Studies have found that it can induce apoptosis by means of mitochondrial apoptosis pathway, endoplasmic reticulum stress apoptosis pathway and m TOR pathway. The pro-apoptotic effect and passible mechanims of AMPK in islet beta cells have been reviewed in this paper.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2018年第1期143-147,共5页
Chinese Journal of Modern Applied Pharmacy
基金
国家卫生计生委共建科学基金项目(WKJ-FJ-13)
福建省卫生系统中青年骨干人才培养项目(2015-ZQN-ZD-23)
