摘要
目的探讨保胎灵胶囊联合间苯三酚治疗先兆早产的临床疗效。方法选取2016年9月—2017年9月在湖北民族学院附属民大医院治疗的先兆早产患者76例,随机分为对照组(38例)和治疗组(38例)。对照组静脉滴注间苯三酚注射液,120 mg加入5%葡萄糖注射液500 mL,滴速为30~40滴/min,依据宫缩情况调整速度至宫缩消失。治疗组在对照组的基础上口服保胎灵胶囊,1.5 g/次,3次/d,连续服用7 d。观察两组患者临床疗效,比较治疗前后两组患者相关临床指标、血清细胞因子水平和宫颈分泌物水平。结果治疗后,对照组和治疗组的总有效率分别为78.95%、94.74%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组药物起效时间和宫缩缓解时间明显短于对照组,且妊娠延长时间明显长于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清前列腺素E2(PGE2)、促肾上腺皮质激素释放激素(CRH)和NO水平显著降低,孕酮(PROG)水平显著增高,同组比较差异具有统计学意义(P<0.05);且治疗组上述血清细胞因子水平改善水平明显优于对照组(P<0.05)。治疗后,两组胎儿纤连蛋白(FFN)、磷酸化胰岛素样生长因子-1(IGFBP-1)和基质金属蛋白酶-9(MMP-9)水平均明显降低(P<0.05);且治疗组上述宫颈分泌物量明显低于对照组(P<0.05)。结论保胎灵联合间苯三酚治疗先兆早产效果明显,可有效延长妊娠时间,具有一定的临床推广应用价值。
Objective To investigate the clinical curative effect of Baotailing Capsules combined with phloroglucinol in treatment of threatened premature labor. Methods Patients（76 cases） with threatened premature labor in University Hospital of Hubei University for Nationalities from September 2016 to September 2017 were randomly divided into control（38 cases） and treatment（38 cases） groups. Patients in the control group were iv administered with Phloroglucinol Injection, 120 mg added into 5% Glucose Injection 500 mL, the dripping speed was 30 — 40 drops/min, adjust the speed based on uterine contraction until uterine contraction disappeared. Patients in the treatment group were po administered with Baotailing Capsules on the basis of the control group, 1.5 g/time, three times daily, and they were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the related clinical indicators, serum cytokine levels, and cervical secretions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 78.95% and 94.74%, respectively, and there were differences between two groups（P〈0.05）. After treatment, the time of drug onset and relieving uterine contraction in treatment group was shorter than that in the control group, but the prolongation time of pregnancy was significantly longer than that in the control group, with significant difference between two groups（P〈0.05）. After treatment, the PGE2, CRH, and NO levels in two groups were significantly decreased, PROG levels were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And the improvement level of these serum cytokine in the treatment group was significantly better than that the control group（P〈0.05）. After treatment, FFN, IGFBP-1, and MMP-9 levels in two groups were significantly decreased（P〈0.05）. And the level of cervical secretions in the treatment group was significantly lower th
出处
《现代药物与临床》
CAS
2018年第1期93-96,共4页
Drugs & Clinic
