摘要
目的观察普罗布考联合瑞舒伐他汀对脑梗死患者血脂、炎性因子等的影响。方法选择2016年4月—2017年4月南宁市第一人民医院神经内科一区收治的脑梗死患者96例作为研究对象,随机数字表法分为观察组48例和对照组48例。2组患者均给予常规治疗,并控制基础疾病。对照组在常规治疗基础上加服瑞舒伐他汀钙片10 mg/次,1次/d;观察组在对照组治疗基础上口服普罗布考片250 mg/次,2次/d。2组均连续治疗6个月。比较治疗前后2组患者TC、TG、HDL-C、LDL-C、hs-CRP、TNF-α、IL-6、PCT、MMP-9水平,对神经功能进行评分,并比较颈动脉内中膜厚度,记录2组患者不良反应。结果与治疗前比较,2组治疗后TC、TG、LDL-C、hs-CRP、TNF-α、IL-6、MMP-9、PCT均下降(P<0.01),HDL-C上升,且治疗后,观察组各指标改善均优于对照组(t=5.439、5.311、3.718、9.248、11.940、2.374、9.094、7.340、3.696,P均=0.000);治疗后观察组NIHSS、颈动脉内中膜厚度显著低于对照组(t=11.227、1.985,P=0.000、0.049)。2组患者治疗期间发生恶心/呕吐、腹泻、腹胀等不良反应发生率比较,差异无统计学意义(P>0.05)。结论普罗布考联合瑞舒伐他汀治疗脑梗死,能有效降低血脂水平,降低炎性反应,改善神经功能。
Objective To investigate the effects of probucol combined with rosuvastatin on blood lipids, PCT and hs-CRP in elderly patients with cerebral infarction. Methods Ninety-six cases of patients with cerebral infarction were selected, which were treated in hospital from April-2016 to April-2017, and they were divided into the observation group （48 cases） and control group （48 eases）. The patients of two groups were all treated with routine treatment and control underlying diseases. The patients of control group were treated with rosuvastatin calcium tablets （10 nag / time, 1 time/d）. Based on control group, the patients of observation group were treated with probucol tablets （250 rag/time, 2 times/d）. The patients of 2 groups were all treated for 6 months in a row. Compare the adverse reactions and changes of TC, TG, HDL-C, LDL-C, hs- CRP, TNF-α, IL-6, PCT, MMP-9 levels, neurological function scores, carotid intima media thickness of the two groups. Re- sults After the appropriate treatment, the TC, TG, LDL-C,hs-CRP, TNF-c~, IL-6, PCT, MMP-9 in the observation group were significantly improved than those in the control group, and the HDL-C in the observation group were significantly higher than those in the control group （ t = 5. 439, t = 5.311, t = 3. 718, t = 9. 248, t = 11. 940, t = 2.374,t = 9.094, t = 7. 340,t = 3. 696 ; all P = 0.000） ; The NIHSS, carotid intima media thickness in the observation group were significantly lower than those in the control group （t = 11. 227, t = 1. 985 ; P = 0. 000, P =0.049） ; There were nausea/vomiting, diarrhea, bloa- ting and other adverse reactions occurred in both two groups, but the difference between groups was not statistically significant （X2 = 0.443, X2 =0.723, X2 =1.435; P= 0.506, P=0.395, P=0.231）. Condusion Probucol combined with rosuv- astatin in the treatment of elderly patients with cerebral infarction can get exact effect, reduce blood lipid and inflammation, improve neurological function, safe and effective, which makes it worthy of
出处
《疑难病杂志》
CAS
2018年第2期117-120,124,共5页
Chinese Journal of Difficult and Complicated Cases
关键词
普罗布考
瑞舒伐他汀
脑梗死
血脂
降钙素原
超敏C反应蛋白
Probueol
Rosuvastatin
Cerebral infarction
Blood lipids
Procalcitonin
Hypersensitive C reactive protein
