胺碘酮联合阿替洛尔治疗冠心病并心律失常的临床分析被引量：25

Clinical analysis of amiodarone combined with atenolol in treatment of coronary heart disease complicated by arrhythmia

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摘要目的观察胺碘酮联合阿替洛尔治疗冠心病并心律失常临床分析。方法收集2015年2月至2017年1月收治的200例冠心病心并律失常患者为研究对象,随机分为观察组(胺碘酮联合阿替洛尔治疗)与对照组(单用胺碘酮治疗),每组100例,对比2组病例治疗总有效率、血清相关因子CD40L、TNF-α及IL-6、血压及心率及不良反应。结果对照组有效率为78%,观察组有效为92%,2组差异有统计学意义(P<0.05)。2组血清相关因子CD40L、TNF-α及IL-6治疗前无统计学意义(P>0.05),治疗后较治疗前明显减低,差异有统计学意义(P<0.05),与对照组相比,治疗后观察组患者血清因子CD40L、TNF-α及IL-6水平明显降低,差异有统计学意义(P<0.05)。2组治疗后血压、心率均较治疗前有显著下降(P<0.05),2组治疗后观察组指标较对照组差异均有统计学意义(P<0.05)。观察组不良反应6例,不良反应率为6%,对照组不良反应28例,不良反应率为28%,差异有统计学意义(P<0.05)。结论应用胺碘酮联合阿替洛尔治疗冠心病并心律失常效果显著,明显优于一般治疗效果,安全性高,值得进一步研究分析和应用。 Objective To investigate the therapeutic effects of amiodarone combined with atenolol in treatment of coronary heart disease complicated by arrhythmia. Methods A total of 200 patients with coronary heart disease complicated by arrhythmia who were admitted and treated in our hospital from February 2015 to January 2017 were randomly divided into observation group and control group,with 100 patients in each group. The patients in observation group were treated by amiodarone combined with atenolol,however,the patients in control group were treated by amiodarone only. The total effective rate,serum levels of CD40 L,TNF-α and IL-6,blood pressure,heart rate and incidence rate of adverse reactions were observed and compared between two groups. Results The total effective rate was 92% in observation group,which was 78% in control group,there was a significant difference beween two groups（ P〈0. 05）. Before treatment there were no significant differences in serum levels of CD40 L,TNF-α and IL-6 between two groups（ P〈0. 05）,however,after treatment the serum levels of CD40 L,TNF-α and IL-6 in observation group were significantly lower than those in control group（ P〈0. 05）. After treatment the blood pressure and heart rate were significantly decreased in both groups,as compared with those before treatment（ P〈0. 05）. Among 100 patients in observation group,6 patients had adverse reactions,with incidence rate of adverse reactions being 6%,however,the 28 patients in control group had adverse reactions,with incidence rate of adverse reactions being28%,there was a significant difference between tow groups（ P〈0. 05）. Conclusion The amiodarone combined with atenolol has obvious therapeutic effects on coronary heart disease complicated by arrhythmia,and the therapeutic effects are superior to those of conventional treatment,therefor,which is worth researching and using further.