摘要
目的探讨声速匹配(SSC)技术对慢性乙型肝炎肝纤维化严重程度的诊断价值。方法选取经临床诊断的慢性乙型肝炎患者137例作为研究组,同期健康志愿者21例作为对照组。根据肝组织病理类型将研究组分为肝纤维化S0、S1、S2、S3、S4组,应用SSC技术测定各组肝组织区域速度指数(ZSI)及区域声速度值(ZSS)。比较各组的ZSI及ZSS,以评价ZSI及ZSS在慢性乙型肝炎肝纤维化诊断中的价值。结果慢性乙型肝炎患者肝纤维化S0、S1、S2、S3、S4期的ZSI分别为(18.78±4.28)m/s、(22.24±4.20)m/s、(27.66±3.35)m/s、(30.47±3.68)m/s、(35.36±4.0)m/s;ZSS分别为(1 558.91±4.38)m/s、(1 562.42±4.22)m/s、(1 567.81±3.33)m/s、(1 570.63±3.69)m/s、(1 575.57±4.12)m/s。ZSI诊断S1期及以上慢性乙型肝炎肝纤维化的ROC曲线下面积为0.854,95%可信区间为(0.796,0.912);以ZSI=21.88 m/s为截断值,诊断肝纤维化的灵敏度、特异度分别为80.60%、74.70%。ZSS诊断S1期及以上慢性乙型肝炎肝纤维化的ROC曲线下面积为0.854,95%可信区间为(0.795,0.911);以ZSS=1 561.5 m/s为截断值,诊断肝纤维化的灵敏度、特异度分别为80.60%、75.80%。结论 ZSI及ZSS对慢性乙型肝炎肝纤维化具有一定的诊断价值,其诊断效能基本一致。SSC可作为诊断肝纤维化的一种评估技术。
ObjectiveTo investigate the diagnostic value of sound speed correction（SSC） for the severity of liver fibrosis in the patients with chronic hepatitis B. MethodsA total of 137 patients clinically diagnosed as chronic hepatitis B were enrolled as study group, and 21 healthy volunteers as control group during the same period. The patients of the study groups were divided into liver fibrosis S0 group, S1 group, S2 group, S3 group and S4 group according to pathological types of hepatic tissues. The zone speed index（ZSI） and zone sound speed（ZSS） of each group were measure by SSC technique. The ZSI and ZSS were compared among all groups for evaluate the diagnostic value of ZSI and ZSS for the severity of liver fibrosis in the patients with chronic hepatitis B. ResultsThe ZSI of the chronic hepatitis B patients with stage S0, S1, S2, S3 and S4 of liver fibrosis were（18.78±4.28）m/s,（22.24±4.20）m/s,（27.66±3.35）m/s,（30.47±3.68）m/s,（35.36±4.0）m/s,respectively. The ZSS of the patients with stage S0, S1, S2, S3 and S4 were（1 558.91±4.38）m/s,（1 562.42±4.22）m/s,（1 567.81±3.33）m/s,（1 570.63±3.69）m/s and （1 575.57±4.12）m/s. respectively. The area under the ROC curve of ZSI was 0.854 for diagnosing stage S1-S4 liver fibrosis in patients with chronic hepatitis B（95% CI：0.796, 0.912）. When the cut-off value of ZSI was 21.88 m/s, the diagnostic sensitivity and specificity for liver fibrosis were 80.60% and 74.70%, respectively. The area under the ROC curve of ZSS was 0.854 for diagnosing liver fibrosis in patients with chronic hepatitis B （95% CI： 0.795, 0.911）. When the cut-off value of ZSS was 1561.5 m/s, the diagnostic sensitivity and specificity for liver fibrosis were 80.60% and 75.80%, respectively. ConclusionZSI and ZSS can achieve a certain diagnostic value and similar diagnostic efficacy for liver fibrosis in the patients with chronic hepatitis B. SSC can be used as a technique for evaluation of liver fibrosis.
出处
《微创医学》
2018年第1期29-33,59,共6页
Journal of Minimally Invasive Medicine
基金
广西柳州市健康安全技术开发与应用研究(编号:2014J030409)
关键词
超声检查
声速匹配
区域速度指数
肝纤维化
Ultrasound
Sound speed correction
Zone speed index
Liver fibrosis
