摘要
目的探讨酮咯酸氨丁三醇复合地佐辛用于腹腔镜卵巢囊肿剔除术超前镇痛效果及对血清五羟色胺(5-HT)和P物质(PS)影响。方法选取符合纳入及排除标准的行腹腔镜卵巢囊肿剔除术的118例为研究对象,根据入院序号分为观察组和对照组两组各59例,观察组采用酮咯酸氨丁三醇复合地佐辛超前镇痛,对照组采用地佐辛超前镇痛,观察比较两组术后不同时间点镇痛效果、术前及术后不同时间点血清5-HT和PS水平以及不良反应发生情况。结果观察组术后1、3及6 h视觉模拟评分及Ramasy评分均低于对照组,差异具有统计学意义(P<0.05)。术前两组5-HT及PS水平比较差异无统计学意义(P>0.05)。术后12、24及48 h 5-HT水平观察组明显低于对照组,术后48 h PS水平观察组高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论酮咯酸氨丁三醇复合地佐辛用于腹腔镜卵巢囊肿剔除术超前阵痛效果显著,可抑制血清5-HT及PS水平,且安全性高。
Objective To investigate effectiveness of Ketorolac Tromethamine combined with Dezocine in application of preemptive analgesia for laparoscopic ovarian cyst resection and its effects on serum 5-hydroxytryptamine( 5-HT) and substance P( PS). Methods selected total of 118 patients with laparoscopic ovarian cyst resection during January 2015 and December 2016,who had met the admittance and exclusion criteria,were divided into control group( n = 59) and observation group( n = 59) according to the number of admission. Observation group was treated with Ketorolac Tromethamine combined with Dezocine for preemptive analgesia,while control group was treated with Dezocine for preemptive analgesia. Analgesia effects at postoperatively different time points,serum 5-HT and PS levels at preoperatively and postoperatively different time points and incidence rate of adverse reactions were observed and compared in two groups. Results Visual analogue scales( VAS) and Ramasy scores at postoperative 1 st,3 thand 6^(th) h in observation group were significantly lower than those in control group( P < 0. 05). There were no significant differences in preoperative 5-HT and PS levels between two groups( P > 0. 05).In observation group,5-HT levels at postoperative 12^(th),24^(th) and 48 thh were significantly decreased than those in control group,while PS level at postoperative 48 thh was significantly higher than that in control group( P < 0. 05). There was no significant difference in incidence rate of adverse reactions between two groups( P > 0. 05). Conclusion Ketorolac Tromethamine combined with Dezocine in application of preemptive analgesia for laparoscopic ovarian cyst resection may achieve good effectiveness and inhibit serum 5-HT and PS levels with good safety.
出处
《临床误诊误治》
2018年第2期69-72,共4页
Clinical Misdiagnosis & Mistherapy
基金
陕西省教育厅科学技术研究项目(2011658)
关键词
酮咯酸氨丁三醇
地佐辛
卵巢囊肿
腹腔镜
镇痛
5羟色胺
P物质
Ketorolac tromethamine
Dezocine
Ovarian cysts
Laparoscopes
Analgesia
5-hydroxytryptamine
Substance P
