摘要
目的观察ICS治疗患者日间血清CD28水平变化规律,并与正常人群进行比较,以探讨CD28水平在哮喘患者人群中的变化,及取样时间是否影响检测结果。方法研究纳入2015年1月~2017年1月于笔者医院接受ICS治疗的哮喘患者82例与正常健康受试者40例,在8:00~17:00,每隔3h取血检测血清CD28水平。比较两组受试者不同时间点CD28水平。结果哮喘患者ICS治疗前血清CD28水平显著高于健康对照组(F1,120=232.1,P=0.000),治疗前哮喘患者CD28水平清晨最高,后逐渐降低;经过ICS治疗之后,各时间点哮喘患者CD28水平显著降低,但在8:00(t=4.59,P<0.01)和11:00(t=3.51,P<0.01)两个时间点仍高于对照组。结论血清CD28水平在哮喘发病中起到重要作用,且具有一定节律性,可作为哮喘患者诊断或治疗的分子标志物或靶点。
Objective To observe the day - time variation of serum CD28 in asthmatic adults treated with ICS and adults without asthma. Methods Serum CD28 level were measured at 3 - hour intervals from 8：00 to 17：00 h in 82 adult participants with asthma and in 40 healthy participants without asthma during Jan 2015 to Jan 2017. CD28 levels at each timepoints of asthma patients before and after ICS therapy and healthy participants were compared by repeated measures analysis of variance. Results The level of CD28 of asthma pa- tients before ICS were significantly higher than heathy control （ F~.~20 = 232.1, P = 0. 000）. The CD28 lever of asthma patients before ICS was highest at 8：00h and continuously reduced during the day. After ICS therapy, the level of CD28 were significantly decreased, and were significantly higher than healthy control group at 8：00h （t =4.59,P 〈0.01 ） and 11：00h （t =-3.51 ,P 〈0.01 ）. Conclusion The level of serum CD28 changed significantly and rhythmically in asthma patients, which may be a potential marker or therapeutic target in the diagnosis or therapy of asthma.
出处
《医学研究杂志》
2018年第2期148-151,共4页
Journal of Medical Research
