摘要
目的分析中国Duchenne型肌营养不良(DMD)患者与正常儿童运动功能的差异,探讨中国DMD患者运动功能变化。方法 2016年4月~2017年8月,对155例DMD患者(DMD组)和24例正常男童(对照组)进行6分钟步行测试、卧立位时间测试、四阶梯试验时间测试及9 m步行时间测试。结果 DMD组6分钟步行距离(6MWD)均值显著小于对照组(t=-9.534,P<0.001),9 m步行时间显著长于对照组(t=-7.460,P<0.001)。两组间的6MWD、9 m步行时间在6.0~6.9岁人群中无显著性差异(P>0.05),在7.0岁以上人群中有非常高度显著性差异(t>2.648,P<0.001)。DMD组卧立位时间和四阶梯试验时间范围分别为1.95~27.27 s、1.18~19.17 s。DMD组6MWD在7.0岁后开始下降。DMD组的9 m步行时间、卧立位时间、四阶梯试验时间分别在7.2岁、5.2岁、5.5岁后开始上升。结论中国DMD患者各项运动功能指标均差于同年龄阶段的正常儿童,并且各项运动指标变化的年龄节点不同。其中卧立位时间测试和四阶梯试验时间测试较早受到疾病的影响。
Objective To analyze the differences of motor function between Chinese patients with Duchenne muscular dystrophy(DMD) and normal children, and to explore the changes of motor function in Chinese DMD patients.Methods From April, 2016 to August, 2017, 155 DMD patients(DMD group) and 24 normal boys(control group) were given 6-minute walk test, timed rise from floor test, 4-stair test, and 9 meters walking time test.Results The 6-minute walk distance(6 MWD) was lower in DMD group than in the control group(t=-9.534, P<0.001),and the 9 meters walking time was higher in DMD group than in the control group(t=-7.460, P<0.001). There was no significant difference in 6 MWD and 9 meters walking time between two groups at the age of 6.0 to 6.9 years(P>0.05); however, the difference was significant after seven years old(t>2.648, P<0.001). The completion times of timed rise from floor test and 4-stair test group were distributed between 1.95 to 27.27 seconds and 1.18 to 19.17 seconds, respectively, in DMD group. The 6 MWD decreased from 7.0 years old, and 9 meters walking time increased from 7.2 years old. The completion time of timed rise from floor test increased from 5.2 years old,and the completion time of 4-stair test increased from 5.5 years old.Conclusion The motor function of Chinese DMD patients is worse than normal children at the same age. The age nodes of the movement indicators are different in DMD patients. The timed rise from floor test and the 4-stair test are earlier affected by the disease.
出处
《中国康复理论与实践》
CSCD
北大核心
2018年第2期214-218,共5页
Chinese Journal of Rehabilitation Theory and Practice
基金
首都临床特色应用研究与成果推广项目(No.Z151100004015025)
北京市科技计划课题(No.Z151100003915126)~~
