摘要
目的探讨扩散峰度成像(diffusion kurtosis imaging,DKI)定量参数对腰椎间盘退变的诊断价值。材料与方法选择81例受检者进行腰椎矢状位常规T2WI及DKI成像,对腰椎间盘进行Pfirrmann分级,并分析腰椎间盘髓核DKI参数平均扩散峰度(mean kurtosis,MK)、平均扩散系数(mean diffusivity,MD)值,与Pfirrmann分级、椎间盘节段及受试者性别的关系。结果 MK值与Pfirrmann分级呈显著正相关(r=0.922,P<0.01),MD值与Pfirrmann分级呈显著负相关(r=-0.921,P<0.01)。L5/S1节段MK值(0.89±0.32)明显高于L1/L2(0.82±0.14)、L2/L3(0.8 4±0.2 3)(P<0.0 5),L5/S1节段M D值(1.8 3±0.3 2)低于L1/L2(1.89±0.14)、L2/L3(1.86±0.19)(P<0.05);各节段椎间盘MK及MD值性别差异无统计学意义(P>0.05)。结论 DKI成像可用于定量评价早期椎间盘退变,MK及MD值与Pfirrmann分级、椎间盘节段具有相关性,而与性别差异无明显相关性。
Objective To investigate the value of diffusion kurtosis imaging （DKI） related parameters in assessing lumbar intervertebral disc degeneration. Materials and Methods： T2WI and DKI were performed on 81 subjects. DKI related parameters： mean kurtosis （MK） and mean diffusivity （MD） of nucleus pulposus （NP） were measured and correlated with Pfrrmann grades, disc level, and gender. ANOVA and post hoc tests were employed to compare MK and MD values of different Pfrrmann grades, as well as the values in different disc levels. Associations between MK, MD values and Pfirrmann grades were tested using Spearman rank correlation. Two-sample t-test was applied for the gender differences. Results： Pfrrmann grades were positively correlated with MK values （r=0.922, P〈0.01） and negatively correlated with MD values （r=-0.921, P〈0.01） in the NP. MK value in L5/S1 level （0.89±0.32） was higher than that in L1/L2 （0.82±0.14） and L2/L3 （0.84±0.23） （P〈0.05） level, MD value in L5/S1 level （1.83±0.30） was lower than that in L1/L2 （1.89±0.14） and L2/L3 （1.86±0.19） （P〈0.05） level. There was no statistical signifcances in MK and MD values of each level between males and females （P〉0.05）. Conclusions： DKI is feasible to assess early lumbar intervertebral disc degeneration. MK and MD values are correlated with Pfrrmann grades and spinal level, and have no correlation with gender.
作者
曾菲菲
查云飞
胡磊
林苑
龚威
陈翩翩
柳柏玉
陆雪松
ZENG Fei-fei;ZHA Yun-fei;HU Lei;LIN Yuan;GONG Wei;CHEN Pian-pian;LIU Bai-yu;LU Xue-song(Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China;Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis ＆ Treatment, Wuhan 430060, China;Department of Biological Engineering, School of Biomedical Engineering, South-Central University for Nationalities, Wuhan 430060, China)
出处
《磁共振成像》
CAS
CSCD
2018年第2期113-116,共4页
Chinese Journal of Magnetic Resonance Imaging
基金
医学信息分析及肿瘤诊疗湖北省重点实验室开放课题基金项目(编号:PJS140011511)~~
关键词
椎间盘退化
腰椎
扩散峰度成像
磁共振成像
Intervertebral disc degeneration
Lumbar vertebrae
Diffusion kurtosis imaging
Magnetic resonance imaging
