摘要
目的观察丹红注射液治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床疗效,探讨其对免疫功能的影响。方法选取2015—2016年上海市奉贤区中心医院收治的AECOPD患者112例,采用随机数字表法分为对照组和研究组,每组56例。对照组患者予以常规治疗,研究组患者在对照组治疗基础上予以丹红注射液治疗;两组患者均连续治疗2周。比较两组患者临床疗效,治疗前后动脉血气分析指标[动脉血二氧化碳分压(PaCO_2)、动脉血氧分压(PaO_2)、pH值]、血清炎性因子[干扰素γ(INF-γ)、肿瘤坏死因子α(TNF-α)、白介素10(IL-10)]水平、T淋巴细胞亚群(CD_3^+细胞分数、CD_4^+细胞分数、CD_8^+细胞分数、CD_4^+/CD_8^+细胞比值)及血清免疫球蛋白[免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)]水平,并观察两组患者治疗期间不良反应发生情况。结果研究组患者临床疗效优于对照组(P<0.05)。两组患者治疗前PaCO_2、PaO_2、pH值及治疗后PaO_2、pH值比较,差异均无统计学意义(P>0.05);治疗后研究组患者PaCO_2低于对照组(P<0.05)。两组患者治疗前血清INF-γ、TNF-α、IL-10水平比较,差异无统计学意义(P>0.05);治疗后研究组患者血清INF-γ、TNF-α、IL-10水平低于对照组(P<0.05)。治疗前两组患者CD_3^+细胞分数、CD_4^+细胞分数、CD_8^+细胞分数、CD_4^+/CD_8^+细胞比值及治疗后CD_8^+细胞分数比较,差异均无统计学意义(P>0.05);治疗后研究组患者CD_3^+细胞分数、CD_4^+细胞分数、CD_4^+/CD_8^+细胞比值高于对照组(P<0.05)。治疗前两组患者血清IgG、IgA、IgM水平及治疗后血清IgM水平比较,差异均无统计学意义(P>0.05);治疗后研究组患者血清IgG、IgA水平高于对照组(P<0.05)。两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论丹红注射液治疗AECOPD患者的临床疗效确切,可有效降低患者血清炎性因子水平,改善患者动脉�
Objective To observe the clinical effect of Danhong injection on acute exacerbation of chronic obstructive pulmonary disease（AECOPD）,to explore its impact on immunologic function.Methods From 2015 to 2016,a total of 112patients with AECOPD were selected in the Central Hospital of Fengxian District,Shanghai,and they were divided into control group and study group according to random number table,each of 56 cases.Patients in control group received conventional treatment,while patients in study group received extra Danhong injection based on conventional treatment;both groups continuously treated for 2 weeks.Clinical effect,arterial blood-gas analysis results（including Pa CO2,PaO2 and p H）,serum levels of inflammatory cytokines（including INF-γ,TNF-αand IL-10）and immune globulin（including IgG,IgA and IgM）,and T-lymphocyte subsets（CD3^＋cell percentage,CD4^＋cell percentage,CD8^＋cell percentage and CD4^＋/CD8^＋cell ratio）before and after treatment were compared between the two groups,and incidence of adverse reactions was observed during the treatment.Results Clinical effect of study group was statistically significantly better than that of control group（P〈0.05）.No statistically significant differences of Pa CO2,PaO2 or p H was found between the two groups before treatment,nor was PaO2 or p H after treatment（P〉0.05）,while Pa CO2in study group was statistically significantly lower than that in control group after treatment（P〈0.05）.No statistically significant differences of serum level of INF-γ,TNF-αor IL-10 was found between the two groups before treatment（P〉0.05）,while serum levels of INF-γ,TNF-αand IL-10 in study group were statistically significantly lower than those in control group after treatment（P〈0.05）.No statistically significant differences of CD3^＋cell percentage,CD4^＋cell percentage,CD8^＋cell percentage or CD4^＋/CD8^＋cell ratio was found between the two groups before treatment,nor was CD8^＋cell percentage after treatment（P〉0.05�
出处
《实用心脑肺血管病杂志》
2017年第12期91-94,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
肺疾病
慢性阻塞性
丹红注射液
治疗结果
免疫
Pulmonary disease, chronic obstructive
Danhong injection
Treatment outcome
Immunity
