摘要
目的分析妥洛特罗贴剂在喘息性疾病患儿中的治疗效果及其对患者肺功能与血清细胞因子水平炎症的影响,为临床治疗提供依据。方法选取2015年6月~2016年6月在本院儿科就诊的120例喘息性疾病患儿作为研究对象,将入选患者随机分为两组,即对照组与观察组,每组各60例。对照组患者采取沙丁胺醇雾化治疗,观察组患者采取妥洛特罗贴进行治疗。比较两组患者疗效及各项指标。结果对照组患者治疗有效率为75.0%,而观察组患者治疗有效率为91.67%;经比较,观察组患者治疗有效率显著高于对照组患者(P<0.05)。两组患者治疗后肺功能均有所好转(P<0.05);治疗后,观察组患者的PEF%(86.09±6.15)显著高于对照组(74.29±4.96)(t=11.569,P=0.000)。观察组患者的喘鸣音持续时间、咳嗽持续时间以及治愈时间均明显少于对照组患者;且两组患者治疗后IL-5、IL-6水平均较治疗前有显著下降(P<0.05),且观察组患者治疗后IL-5、IL-6水平较对照组患者治疗后水平更低(P<0.05)。两组患者治疗后嗜酸粒细胞、嗜酸粒细胞阳离子蛋白水平均较治疗前有显著下降(P<0.05),且观察组患者治疗后嗜酸粒细胞、嗜酸粒细胞阳离子蛋白水平较对照组患者治疗后水平更低(P<0.05)。结论妥洛特罗贴剂治疗喘息性疾病患儿临床效果显著且安全,能够显著改善肺功能,明显降低血清炎症因子水平。
Objective To analyze the therapeutic effect of tolobuterol patch in children with wheezing disease and its influence on pulmonary function and serum cytokine level inflammation in order to provide the basis for clinical treatment. Methods From June 2015 to June 2016,120 pediatric patients with wheezing diseases were randomly divided into two groupscontrol group and observation group,each group 60 patients.The patients in the control group were treated with salbutamol atomization,and the patients in the observation group were treated with tolobuterol.The curative effect and indexes of the two groups were compared. Results The effective rate of treatment in the control group was 75.0% and that in the observation group was 91.7%.The effective rate of treatment in the observation group was significantly higher than that in the control group（P 〈0.05）.The pulmonary function of the two groups was improved after treatment（P 〈0.05）,and the pulmonary function index （PEF%）of the observation group（86.09±6.15） was significantly higher than that of the control group（74.29±4.96）（t=11.569,P=0.000）.The duration of wheezing,cough and cure time in the observation group were significantly less than those in the control group.The levels of IL-5 and IL-6 in both groups were significantly lower than those before treatment（P 〈0.05）,The level of IL-5 and IL-6 in the observation group was lower than that in the control group（P〈0.05）.The levels of eosinophil and eosinophil cationic protein in both groups were significantly lower than those before treatment （P〈0.05）.The levels of eosinophil and eosinophil cationic protein in the observation group were lower than those in the control group（P〈0.05）. Conclusion The clinical effect of tolobuterol in treating children with wheezing diseases is significant and safe.It can significantly improve pulmonary function and decrease the level of serum inflammatory factors.
出处
《中国医药科学》
2017年第24期54-57,共4页
China Medicine And Pharmacy
基金
广东省惠州市科技计划项目(20150809)
