摘要
目的探讨乳腺放射状瘢痕/复杂硬化性病变的(RS/CSL)临床病理特点。方法收集2014年1月—2016年12月收治的RS/CSL临床资料,分析其病理形态学及免疫组化特点,并复习文献。结果 6例患者年龄34~72岁,2例术前考虑为乳腺癌。病变范围0.3~1.8 cm,瘢痕中央伴胶原变性,周围导管及小叶由中央向四周放射状分布,硬化区可见挤压变形的腺管,可呈尖角,常见导管上皮增生、旺炽性增生,2例局灶伴轻度不典型增生,有时可见导管上皮簇状甚至单个分布,也可见良性的小腺管侵犯神经。免疫组化标记SMA、P63、calponin、CK5/6显示绝大部分导管周边肌上皮存在,硬化区内少量小导管周边染色缺失;导管上皮增生区显示CK5/6、CK-H镶嵌性表达,个别病例局灶呈阴性。结论乳腺RS/CSL少见,需要全面掌握其形态特点及鉴别诊断,避免误诊。
Objective This paper tries to investigate the clinicopathological features of the breast radial scar/complex sclerosing lesions（RS/CSL）. Methods The clinical data of 6 cases of RS/CSL from January 2014 to December 2016 were collected, and the pathological and immunohistochemical features were analyzed. Related literatures were also reviewed. Results The ages ranged from 34 to 72 years of the 6 cases, 2 cases were considered as breast cancer. The size was 0.3~1.8 cm,ducts and lobules radiating from the central with collagen degeneration, the sclerosing region showed a compressive deformation of the gland with sharp angles, often with ductal epithelial hyperplasia, florid hyperplasia, 2 cases with mild atypical hyperplasia focally, some ductal epithelial clusters or even single distribution, benign gland invading nerve could be observed. SMA, P63, calponin, CK5/6 showed the presence of the majority of peripheral myoepithelial, with few deficiency in the sclerosing region. CK5/6 and CK-H mosaic were expressed in hyperplasia area, and the focal area was negative. Conclusion RS/CSL is rare and the morphological features and differential diagnosis need to be fully understood so as to avoid misdiagnosis.
出处
《中外医疗》
2017年第32期26-28,共3页
China & Foreign Medical Treatment
基金
无锡市卫生和计划生育委员会基金(Q201505)
