摘要
骨质疏松症是一种以骨量减低和骨组织微结构退化为特征的骨骼疾病。随着社会人口老龄化的进展,骨质疏松症的发病率将会越来越高,尤其是绝经期女性,其发生骨质疏松症的风险较男性更高。骨质疏松症所带来的问题日趋严重,其给社会及家庭带来巨大的负担,尤其是骨质疏松症导致的身体重要部位的骨折。目前骨质疏松症的治疗方法有限,药物的治疗虽然有一定成效,但是药物并不能彻底根治骨质疏松症且药物需长期使用,因此药物的副作用的问题不容忽视。在人类的肠道定植着数量繁多且对机体健康有着重要作用的菌群,其中益生菌的健康效应也逐渐被挖掘。目前研究发现益生菌对机体诸多的疾病有显著的疗效,其中益生菌和骨质疏松症也有着密切的关系。益生菌可以通过复杂的方式干预骨质疏松症,但其具体机制仍未阐明。本文通过相关的报道进行综述,并从(1)炎症因子;(2)基因、配体及信号通路;(3)破骨细胞;(4)钙离子吸收等方面探讨益生菌干预骨质疏松症的可能机制,为骨质疏松症的防治提供新的思路。
Osteoporosis is a bone disease characterized by loss of bone mass and tissue microstructure deterioration.With the aging of our society,the incidence rate of osteoporosis is going to increase gradually,especially among postmenopausal women,who have higher risk for osteoporosis than man.Such disease brings the society and the family a huge burden,poses serious threat to human health,especially when major fractures occur.Nowadays,the treatments of osteoporosis are limited.Although drug treatment has certain effect,osteoporosis cannot be cured completely.Due to the need for long-term medication,the side effects of drugs cannot be ignored.In the human intestinal tract,a large number of bacteria colonize,which are beneficial to human health.The health effects of probiotics are gradually being excavated.Current studies found that probiotics have a significant effect on many diseases;moreover,there is a close relationship between probiotics and osteoporosis.Probiotics could intervene in the development of osteoporosis through complicated pathways,but the specific mechanisms remain unclear.In order to provide newideas for the prevention and treatment of osteoporosis,this paper reviews related reports,and discusses the possible mechanisms of 1）inflammatory factors,2） genes,ligands and signaling pathways,3） osteoclasts,and 4） calcium absorption.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2018年第1期107-110,共4页
Chinese Journal of Osteoporosis
基金
山西省应用基础研究项目(201701D121097)
关键词
骨质疏松症
肠道菌群
益生菌
机制
Osteoporosis
Gut microbiota
Probiotics
Mechanism
