摘要
目的探讨替莫唑胺联合放射治疗复发性恶性脑胶质瘤的临床疗效。方法选取52例复发性恶性脑胶质瘤患者为研究对象,随机将患者分为对照组和实验组,每组26例,给予对照组患者三维适形放射治疗,实验组在对照组的基础上给予口服150 mg/(m^2·d)替莫唑胺治疗,分析比较2组患者的临床疗效及不良反应,并对2组患者进行为期1年的随访,记录患者生存状态。结果实验组患者临床治疗有效率为73.08%,明显高于对照组的46.15%(P<0.05)。治疗后实验组患者的卡氏评分及生活质量改善率明显高于对照组(P<0.05)。2组临床均未见治疗性死亡患者,主要临床不良反应表现为中轻度白细胞计数减少、放射性脑水肿、恶心呕吐、发热、骨髓抑制及贫血等症状(P>0.05)。实验组患者1年随访生存率为92.31%,明显高于对照组的84.62%;复发率(3.85%)明显低于对照组的15.38%(P<0.05)。结论替莫唑胺联合放射治疗是复发性恶性脑胶质瘤较为理想的治疗方式,对于改善患者生活质量、提高患者生存率有积极作用,值得临床推广应用。
Objective To investigate the clinical efficacy of temozolomide combined with radiotherapy for recurrent ma- lignant glioma. Methods 52 patients with recurrent malignant glioma were randomly divided into the control group and the ex- perimental group, each with 26 eases. The control group received three dimensional eonformal radiation therapy, The experimental group on the basis of the control group was treated with 150 mg / （m^2·d） temozolomide treatment,the clinical efficacy and adverse reactions of the 2 groups were analyzed and compared. The 2 groups of patients were followed up for 1 year. The survival status of the patients was recorded. Results The effective rate of clinical treatment was 73.08% in the experimental group, which was significantly higher than that of the control group （46.15 % , P 〈 0.05 ）. The improvement rate of Kyle score and quality of life in the experimental group was significantly higher than that of the control group（ P 〈 0.05 ）. The main clinical adverse events were mild to moderate leukopenia, radioactive brain edema, nausea and vomiting, fever, myelosuppression and anemia（ P 〉 0.05 ）. The 1 -year follow-up survival rate was 92.31% in the experimental group, which was significantly higher than that of the control group （84.62%）. The recurrence rate （3.85 % ） was significantly lower than that of the control group （ 15.38% , P 〈 0.05 ）. Conclusion Temozolomide combined with radiotherapy for recurrent malignant brain glioma is effective, and it has positive effect on improving the quality of life and survival rate of patients, which is worthy of clinical application.
出处
《实用癌症杂志》
2018年第2期211-213,共3页
The Practical Journal of Cancer
关键词
替莫唑胺
放射治疗
恶性脑胶质瘤
临床疗效
Temozolomide
Radiotherapy
Malignant brain glioma
Clinical curative effect
