摘要
目的观察亚胺培南联合谷氨酰胺对腹部手术术后感染伴脓毒血症患者治疗的临床效果。方法选取2014年12月-2016年8月入住医院的70例腹部手术术后感染伴脓毒血症患者为研究对象,分为试验组和对照组,每组各35例,对照组予以注射用亚胺培南/西司他丁钠静脉滴注1g每次,每日2次,试验组在对照组的基础上予以注射用丙氨酰谷氨酰胺静脉滴注20g每次,每日1次,两组患者均用药2周;治疗结束后分析两组患者临床疗效,比较两组患者白细胞计数、APACHEⅡ评分、C-反应蛋白(CRP)、PCT(PCT)、内毒素、白细胞计数恢复正常时间、住院时间、体温恢复正常时间等指标及不良反应发生情况。结果治疗后试验组临床总有效率为91.43%,高于对照组(P<0.05);治疗后两组患者白细胞计数水平、APACHEⅡ评分、CRP、PCT及内毒素水平均降低,血小板计数水平均升高(P<0.05),但试验组上述指标均优于对照组;试验组白细胞计数恢复正常时间、住院时间以及体温恢复正常时间均短于对照组(P<0.05)。结论亚胺培南联合谷氨酰胺治疗腹部手术后感染伴脓毒血症具有很好的抗感染效果,可促进患者恢复。
OBJECTIVE To observe the clinical effect of imipenem combined with glutamine on treatment of infection patients complicated with sepsis after abdominal surgery.METHODS From Dec 2014 to Aug 2016,a total of70 patients who had infections and were complicated with sepsis after abdominal surgery were recruited as the study objects and divided into the experimental group and the control group,with 35 cases in each group.The control group was given intravenous drip of imipenem-cilastatin sodium injection,1 g once,twice a day,while the experimental group was given additional intravenous drip of alanylglutamine on basis of the treatment of the control group,20 g once,once a day;the patients of both groups were treated with drugs for 2 weeks.The clinical curative effects were observed after the treatment,the indexes such as white blood cells counts,APACHE Ⅱscore,C-reactive protein（CRP）,procalcitonin（PCT）,endotoxin,time of recovery of white blood cells counts,length of hospital stay and time of recovery of body temperature as well as the incidence of adverse reactions were observed and compared between the two groups of patients.RESULTS The total effective rate of clinical treatment of the experimental group was 91.43%,higher than that of the control group（P〈0.05）.The white blood cells counts level,APACHE Ⅱscore,CRP level,PCT level and endotoxin level of the two groups of patients were reduced after the treatment,the level of platelets counts was elevated（P〈0.05）,however,the above indexes of the experimental group were better than those of the control group.The time of recovery of white blood cells counts,length of hospital stay and time of recovery of body temperature were shorter in the experimental group than in the control group（P〈0.05）.CONCLUSIONImipenem combined with glutamine can achieve remarkable effect on treatment of the infection patients complicated with sepsis after abdominal surgery and facilitate the recovery of the patients.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2018年第2期233-235,242,共4页
Chinese Journal of Nosocomiology
基金
山东省卫生厅科研基金资助项目(160911)
