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孕期糖尿病与产后糖脂代谢紊乱及高血压的相关性研究 被引量:6

Study on the correlation of gestational diabetes mellitus of pregnant women leading to postpartum hypertension and metabolic disorders
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摘要 目的:研究孕期糖尿病患者产后糖脂代谢紊乱及高血压的风险。方法:选取2014年3月-2016年5月来本院建档,完成了系统产检,最后在本院分娩的560名孕妇作为研究对象。按照孕期糖尿病的诊断标准将纳入研究者分为孕期糖尿病组(简称糖尿病组)与正常的对照组。统计比较产前与产后资料:两组孕妇年龄、体重、身高、血压、空腹血糖(FPG)、空腹胰岛素(FINS)、口服葡萄糖耐量试验(OGTT)、总胆固醇(TCH)、高/低密度脂蛋白(HDL/LDL)、甘油三酯(TG)、游离脂肪酸(FFA)、胰岛素抵抗指数(HOMA-IR)与胰岛β细胞的分泌功能(HBCI)在产前与产后的差异,采用logistic回归分析产前各相关因素和产后糖脂代谢紊乱及高血压的相关性,筛选出和糖脂代谢紊乱及高血压相关的影响因子。结果:糖尿病组的FFA、TG、FPG、FINS、OGTT、HOMA-IR高于对照组;HBCI、HDL低于对照组;TCH、LDL两组差异无统计学意义。产后1年随访记录糖尿病组的收缩压和舒张压,TG、LDL、OGTT、HOMA-IR高于对照组;HDL低于对照组;FFA、TCH、FPG、FINS、HBCI两组指标差异无统计学意义。结论:HBCI与HOMA-IR为产后糖代谢异常的相关性因素,BMI,TG与HDL为产后脂代谢异常的相关性因素,BMI,HOMA-IR为产后高血压的相关性因素。 Objective: To study the risk of hypertension and metabolic disorders of postpartum women with gestational diabetes mellitus (GDM), and to explore the relevant factors leading to hypertension and metabolic disorders. Meth- ods: From March 2014 to May 2016, 560 pregnant ,women who had completed system antenatal examination and given birth in the first people's hospital of huzhou city hospital were recruited into this study. All pregnant women were divid- ed into GDM group or control group (NC group) according to whether diagnosed GDM during pregnancy. Age, body mass index (BMI), height, blood pressure, fasting plasma glucose (FPG), fasting insulin (FINS), glucose tolerance test (OGTT), total cholesterol (TCH), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG), free fatty acid (FFA), insulin resistance index (HOMA-IR), and pancreatic t]-cell secretion (HBCI) of preg- nant women were compared between the two groups or between prenatal and postpartum of women. Logistic regression was used to analyze the correlation of GDM leading to postpartum hypertension and metabolic disorders. Results: The level of FFA, TG, FPG, FINS, OGTT and HOMA-IR of women in GDM group were significantly higher than those of women in control group, and the level of NC, HBCI and HDL of women in GDM group were significantly lower than those of women in NC group, but the level of TCH and LDL had no significant difference between the two groups. At postpartum one year, the level of systolic blood pressure, diastolic blood pressure, TG, LDL, OGTT and HOMA -IR of women in GDM group were significantly higher than those of women in NC group, and the level of HDL of women was significantly lower than that of women in NC group, while the level of FFA, TCH, FPG, FINS and HBCI of women had no significant difference between the two groups. Conclusion: HBCI and HOMA-IR are the correlation factors of postpartum glucose metabolism abnormality, and BMI, TG and HDL are
作者 诸帆
出处 《中国计划生育学杂志》 2018年第1期29-33,共5页 Chinese Journal of Family Planning
关键词 孕期糖尿病 高血压 代谢紊乱 胰岛素抵抗指数 Pregnancy diabe'tes mellitus Hypertension Metabolic disorders
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