摘要
目的:检测可溶性尿激酶型纤溶酶原激活物受体(suPAR)在肾病综合征患者血清中的水平,结合临床资料及肾活检病理分型分析其临床意义。方法:将70例肾病综合征患者根据肾活检病理类型分为膜性肾病组(MN)、糖尿病肾病组(DN),微小病变性肾小球病组(MCD),局灶节段性肾小球硬化症(FSGS)组及正常对照组,采用酶联免疫吸附试验法分别检测血清suPAR水平,比较不同组别suPAR水平的变化,并分析与临床参数之间的关系。结果:FSGS、MCD、MN和DN组肾病综合征患者血清suPAR水平明显高于正常对照组(P<0.001),FSGS组和MN组血清suPAR水平显著高于MCD组(P=0.013,P=0.029),而FSGS组和MN组血清suPAR水平差异无统计学意义;血清suPAR水平与年龄、血肌酐、尿素氮、免疫球蛋白IgA、免疫球蛋白Ig G呈正相关(rs=0.401 P=0.001;rs=0.286,P=0.016;rs=0.249,P=0.037;rs=0.245,P=0.041;rs=0.247,P=0.039),与eGFR、血红蛋白、血小板呈负相关(rs=-0.265,P=0.026;rs=-0.237,P=0.048;rs=-0.309,P=0.009)。结论:FSGS组血清suPAR水平显著高于MCD组,有望成为区别FSGS与MCD的生物标志物。
Objective： To detect the levels of serum soluble urokinase-type plasminogen activators receptor（ suPAR） in patients with nephrotic syndrome,and to analyze its association with the clinical data and the renal pathological classification.Methods： The serum levels of suPAR in 70 nephrotic syndrome patients with membranous nephropathy（ MN）,diabetic nephropathy（ DN）,minimal change kidney disease（ MCD） and focal segmental glomerular sclerosis（ FSGS） was detected by enzyme-linked immunosorbent assay.The association between the clinical and pathological parameters and suPAR levels were analyzed.Results： SuPAR levels of nephrotic syndrome patients in FSGS,MCD,MN and DN group were significantly higher than those of the normal control group（ P〈0.001）.The levels of suPAR in patients with FSGS and MN were significantly higher than those in patients with MCD（ P =0.013,P = 0.029）,while there was no significant difference of suPAR between FSGS and MN.Serum suPAR level was positively correlated with age,serum creatinine,blood urea nitrogen,immunoglobulin IgA,and immunoglobulin IgG（ rs= 0.401,P = 0.001; rs=0.286,P = 0.016; rs= 0.249,P = 0.037; rs= 0.245,P = 0.039; rs= 0.247,P = 0.039） and negatively correlated with eGFR,hemoglobin and platelets（ rs=-0.265,P = 0.026; rs=-0.237,P = 0.048）.Conclusion： The serum suPAR level in patients of FSGS was significantly higher than that of patients with MCD,which may be a biomarker for distinguishing FSGS and MCD.
出处
《中国中西医结合肾病杂志》
2017年第8期687-691,共5页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
国家自然科学基金资助项目(No.81270808)
辽宁省自然科学基金资助项目(No.201602821)
辽宁省高等学校重大科技平台免疫皮肤病学重点实验室自主创新项目(No.201303)
沈阳市科技计划项目(No.F16-205-1-40)
